| 5-羟色胺_7 受体介导刺激中缝背核对视交叉上核光敏神经元单位放电的抑制效应 |
| |
| 引用本文： | 蒋星红,魏晓萍,张惠琴,刘运林,俞光第,印其章. 5-羟色胺_7 受体介导刺激中缝背核对视交叉上核光敏神经元单位放电的抑制效应[J]. 中国神经科学杂志, 1999, 0(3) |
| |
| 作者姓名： | 蒋星红 魏晓萍 张惠琴 刘运林 俞光第 印其章 |
| |
| 作者单位： | 苏州医学院神经生物学研究室!苏州215007 |
| |
| 摘 要： | 观察刺激中缝背核（ＤＲ）对大鼠视交叉上核（ＳＣＮ）光敏神经元单位放电的影响,并进行药理学分析。结果表明：刺激ＤＲ能明显抑制ＳＣＮ神经元光诱发放电。这种抑制作用能被５ ＨＴ２／７受体拮抗剂ｒｉｔａｎｓｅｒｉｎ 阻断,但不能被选择性５ ＨＴ２ 受体拮抗剂１ ＮＰ阻断。对５ ＨＴ７ 有较高亲和力的神经阻断剂ｃｌｏｚａｐｉｎｅ也能阻断刺激ＤＲ的抑制效应。实验结果提示,刺激ＤＲ对ＳＣＮ 光敏神经元放电的抑制,可能是通过５ ＨＴ７ 样受体起作用的
|
| 关 键 词： | 视交叉上核 中缝背核 光敏神经元 clozapine ritanserin |
5 HT_7 RECEPTOR MEDICATES THE INHIBITORY EFFECT OF DORSAL RAPHE NUCLEUS STIMULATION ON UNIT DISCHARES OF LIGHT SENSITIVE NEURONS OF SUPRACHIASMATIC NUCLEUS |
| |
| JIANG Xing hong,WEI Xiao ping,ZHANG Hui qing,LIU Yun lin,YU Guang di,YIN Qi zhang. 5 HT_7 RECEPTOR MEDICATES THE INHIBITORY EFFECT OF DORSAL RAPHE NUCLEUS STIMULATION ON UNIT DISCHARES OF LIGHT SENSITIVE NEURONS OF SUPRACHIASMATIC NUCLEUS[J]. Neuroscience Bulletin, 1999, 0(3) |
| |
| Authors: | JIANG Xing hong WEI Xiao ping ZHANG Hui qing LIU Yun lin YU Guang di YIN Qi zhang |
| |
| Abstract: | The effect of dorsal raphe nucleus (DR) stimulation on the unit discharge of suprachiasmatic nucleus (SCN)neurons was studied and analyzed pharmacologically in the Wistar rats.Experimental results showed that DR stimulation could significantly inhibit the light induced discharge of SCN neurons.This inhibitory effect of DR stimulation on the discharge of light sensitive SCN neurons was blocked by ritanserin(5 HT 2/7 antagonist) but not by 1 NP (5 HT 2 selective antagonist). Neuroleptic clozapine which has a moderate affinity to 5 HT 7 receptor could also block the inhibitory effect of DR stimulation. It was suggested that the inhibitory effect of DR stimulation on the light induced discharges of SCN neuron might be mediated by 5 HT 7 like receptor. |
| |
| Keywords: | suprachiasmatic nucleus dorsal raphe nucleus light sensitive neuron clozapine ritanserin |
| 本文献已被 CNKI 等数据库收录！ |
