|
|||||
|
|
| Changes of Apoptosis in Rats of Acute Ischemic Renal Injury under Treatment of Tetrandrine | |
| 作者姓名： | QIAN Ling-mei |
| 作者单位： | [1]DepartmentofEmergenceMedicine [2]DepartmentofNephrology,theFirstAffiliatedHospitalofNanjingMedicalUniversity,NanjingJiangsu210029,P.R.China |
| 基金项目： | This paper was supported by the Natural Science Foundation of Nanjing Medical University (NY970 55) |
| 摘 要： | Objective To elucidate the effect of tetrandrine on acute ischemic renal injury and its relation with apoptosis.Methods A model for bilateral post-ischemic renal injury in rats was developed by clamping renal pedicles for 45 min.Renal tissular DNA fragmentation analysis and renal tissular HE staining were used.Also quantitative analysis of apoptosis in injured renal tubular epithelium was carried out by using TdT-mediated dUTP nick and labeling(TUNEL).Results Apoptosis of renal tubular epithelium increased in acute ischemic renal injury.Tetrandrine could remarkably decrease the level of apoptosis in injured renal tubule while protecting renal tissue against the ischemic injuries.Conclusion Tetrandrine could adjust the level of apoptosis in renal tubular epithelium and alleviate renal tissular injury. |
| 关 键 词： | 粉防己甲素 凋亡 急性肾缺血损伤 中药药理 |
Changes of Apoptosis in Rats of Acute Ischemic Renal Injury under Treatment of Tetrandrine |
|
| QIAN Ling mei,WANG Xiao yunLENG Jing.Changes of Apoptosis in Rats of Acute Ischemic Renal Injury under Treatment of Tetrandrine[J].Acta Universitatis Medicinalis Nanjing,2002,16(1):6-11. | |
| Authors: | QIAN Ling mei WANG Xiao yunLENG Jing |
| Institution: | 1. Department of Emergence Medicine,Deparment of Nephrology,the First Affiliated Hospital of Nanjing Medical University,Nanjing Jiangsu 210029,P.R.China;Department of Emergence Medicine,Department of Pathology,Nanjing Medical University,Nanjing Jiangsu 21002 2. Department of Emergence Medicine,Deparment of Nephrology,the First Affiliated Hospital of Nanjing Medical University,Nanjing Jiangsu 210029,P.R.China 3. Department of Emergence Medicine,Department of Pathology,Nanjing Medical University,Nanjing Jiangsu 210029,P.R.China |
| Abstract: | ObjectiveTo elucidate the effect of tetrandrine on acute ischemic renal injury and its relation with apoptosis. MethodsA model for bilateral post ischemic renal injury in rats was developed by clamping renal pedicles for 45 min. Renal tissular DNA fragmentation analysis and renal tissular HE staining were used. Also quantitative analysis of apoptosis in injured renal tubular epithelium was carried out by using TdT mediated dUTP nick and labeling (TUNEL). ResultsApoptosis of renal tubular epithelium increased in acute ischemic renal injury. Tetrandrine could remarkably decrease the level of apoptosis in injured renal tubule while protecting renal tissue against the ischemic injuries. ConclusionTetrandrine could adjust the level of apoptosis in renal tubular epithelium and alleviate renal tissular injury. |
| Keywords: | tetrandrine apoptosis acute ischemic renal injury |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
| 点击此处可从《南京医科大学学报》浏览原始摘要信息 | |
| 点击此处可从《南京医科大学学报》下载免费的PDF全文 | |