Differential inhibition of biphenyl hydroxylation in perfused rat liver |
| |
| Authors: | G. F. Kahl W. Müller R. Kahl H. G. Jonen K. J. Netter |
| |
| Affiliation: | (1) Pharmakologisches Institut der Universität Mainz, Obere Zahlbacher Straße 67, D-6500 Mainz, Federal Republic of Germany;(2) Institut für Pharmakologie und Toxikologie der Universität Marburg, Lahnberge, D-3550 Marburg/Lahn, Federal Republic of Germany |
| |
| Abstract: | Summary A differential inhibition of biphenyl hydroxylation by  -naphthoflavone and metyrapone was observed in isolated pefused rat liver. -Naphthoflavone inhibited 2- and 4-hydroxylation in livers from  -naphthoflavone-pretreated animals but had no effect on both reactions in livers from phenobarbital-pretreated animals. Metyrapone inhibited 2- and 4-hydroxylation in phenobarbital-stimulated livers, but only insignificant inhibition of 2-hydroxylation and a slight enhancement of 4-hydroxylation by metyrapone was observed in -naphthoflavone-stimulated livers.Conjugation of 2-hydroxybiphenyl and 4-hydroxybiphenyl by isolated perfused livers was also studied. 4-Hydroxybiphenyl preferentially formed sulphates in livers from untreated animals but after induction glucuronidation was as effective as sulphation or even exceeded sulphation. Only glucuronic acid conjugates of 2-hydroxybiphenyl were detected. |
| |
| Keywords: | Biphenyl metabolism Conjugation Induction Differential inhibition Isolated rat liver |
| 本文献已被 SpringerLink 等数据库收录！ |
