婴儿色素性神经外胚瘤的组织病理及超微结构观察

作者对３例婴儿色素性神经外胚瘤进行了超微结构和免疫组化等研究，结果表明，肿瘤呈局部浸润性生长，并主要由神经母细胞样小细胞和含色素细胞组成；超微结构示小细胞胞浆内含膜性分泌颗粒，花环状多聚核糖体，可见核分裂相，色素细胞含大量黑色素体和微丝；免疫组化结果显示两种瘤细胞对ＮＳＥ及Ｖｉｍｅｎｔ均呈阳性反应，而Ｓ－１００蛋白阴性，表明该肿瘤细胞较幼稚且生长活跃，提示其有复发和恶变的潜能。本文还对肿瘤细胞和胚胎眼杯细胞的同源性进行了讨论。

Histopathological and ultrastructural studies of melanomatic neuroectodermal tumor of infancy

Three cases of melanomatic neuroectodermal tumor of infancy (MNTI)were studied. The tumor mainly consisted of small neuroblastic-like cells and pigmented large cuboidal cells, and infiltrated adjacent tissues. The main ultrastructural charactristics were the presence of some membranebound dense-core secretory granules, numerous free ribosomes and polysomes aggregated in rosettes, occasional mitoses in the small cells; and four ribosomes and olysomes aggregated in rosettes, occasional mitoses in the small cells ;and four types of membranebound pigment granules corresponding to melanosomes at different stages of maturation in the pigment cells. immunohistochemical results indicated that both of main cells were positive reaction for NSE,negative for S-100. These facts suggested they are immature in and malignancy. Further, the isogenesis of the tumor cells and embryo optic cup cells were discussed.