复方绞股蓝对金地鼠颊囊癌前病变的疗效观察

本实验采用ＤＭＢＡ（二甲基苯丙蒽）丙酮局部涂抹法成功地建立了金地鼠颊囊癌前病变的动物模型。与此同时应用复方绞股蓝进行了对口腔粘膜癌前病变阻断的实验研究。结果显示：绞股蓝对口腔粘膜癌前病变的阻断部位发生在均质型白斑到颗粒状白斑或疣状白斑阶段。先服绞股蓝后涂ＤＭＢＡ组优于边涂边服组。实验证明绞股蓝具有防癌和抗癌功能，在口腔粘膜癌前病变的防治中具有应用前景，其抗癌机理还有待于作更深入的研究。

Observation of effectiveness of compound Gynostemma Pentaphyllum Mak in golden hamster cheek pouch''s premalignancy

Premalignant model was establlished suscessfully in this study. At the same time,we applied compound Gynostemma Pentaphyllum Mak to conduct experimental research to block development of oral mucosal premalignancy. The results showed from uniform to granular or verrucous leukoplakia,there was the stage in which Gynostemma Pentaphyllum Mak could block oral mucosal premalignance. The group which was firstly given to Gynostemma Pentaphllum Mak then smeared was more advantageous than the one which firstly smeared then given to the same drug. The experimentation demonstrated that Gynostemma Pentaphyllum had the functions of preventing and resisting cancer. There will be applied prospect in preventing and treating oral mucosal premalignancy. We should make further research in the future.