A 15-day course of donepezil modulates spectral EEG dynamics related to target auditory stimuli in young,healthy adult volunteers |
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Institution: | 1. Sleep Medical Center, Osaka Kaisei Hospital, Osaka, Japan;2. Department of Oral Anatomy and Neurobiology, Osaka University Graduate School of Dentistry, Osaka, Japan;3. Sleep Medicine Center, Osaka University Hospital, Osaka, Japan |
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Abstract: | ObjectiveTo identify possible electroencephalographic (EEG) markers of donepezil’s effect on cortical activity in young, healthy adult volunteers at the group level.MethodsThirty subjects were administered a daily dose of either 5 mg donepezil or placebo for 15 days in a double-blind, randomized, cross-over trial. The electroencephalogram during an auditory oddball paradigm was recorded from 58 scalp electrodes. Current source density (CSD) transformations were applied to EEG epochs. The event-related potential (ERP), inter-trial coherence (ITC: the phase consistency of the EEG spectrum) and event-related spectral perturbation (ERSP: the EEG power spectrum relative to the baseline) were calculated for the target (oddball) stimuli.ResultsThe donepezil and placebo conditions differed in terms of the changes in delta/theta/alpha/beta ITC and ERSP in various regions of the scalp (especially the frontal electrodes) but not in terms of latency and amplitude of the P300-ERP component.ConclusionOur results suggest that ITC and ERSP analyses can provide EEG markers of donepezil’s effects in young, healthy, adult volunteers at a group level.SignificanceNovel EEG markers could be useful to assess the therapeutic potential of drug candidates in Alzheimer’s disease in healthy volunteers prior to the initiation of Phase II/III clinical studies in patients. |
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Keywords: | Donepezil EEG markers Event-related potential Inter-trial coherence Event-related spectral perturbation |
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