Combination of Microwave Ablation and Percutaneous Osteoplasty for Treatment of Painful Extraspinal Bone Metastasis |
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| Institution: | 1. Departments of Oncology, Teng Zhou Central People’s Hospital Affiliated to Jining Medical College, 181 Xingtan Road, Tengzhou, Shandong Province 277500, China;2. Hepatobiliary and Vascular Surgery, Teng Zhou Central People’s Hospital Affiliated to Jining Medical College, 181 Xingtan Road, Tengzhou, Shandong Province 277500, China;3. Department of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China;4. Department of Oncology, Zouping People''s Hospital, Binzhou City, China;5. Department of Radiation Oncology, Peking University Third Hospital, No. 49, Beijing, China;1. Division of Interventional Radiology, Vanderbilt University Medical Center, 1161 Medical Center Drive, CCC-1118 Medical Center North, Nashville, TN 37232;2. Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee;3. Division of Hepatobiliary Surgery and Liver Transplantation, Vanderbilt University School of Medicine, Nashville, Tennessee;4. Vanderbilt University School of Medicine, Nashville, Tennessee;1. Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York;2. Department of Medicine, Weill Cornell Medical College, New York, New York;3. Interventional Radiology Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York;4. Department of Pharmacy, Memorial Sloan Kettering Cancer Center, New York, New York;5. Department of Radiology, Weill Cornell Medical College, New York, New York;1. Penn Image-Guided Interventions Laboratory, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania;2. Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania;3. Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;4. Department of Radiology and IVR Center, Nara Medical University, Kashihara-city, Nara, Japan;5. Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, Texas;1. Service d''Imagerie Médicale, Centre hospitalier universitaire Henri-Mondor, Université Paris Est, 51 Avenue du Maréchal de Lattre de Tassigny, Créteil 94010, France;2. Service de Médecine Nucléaire, Centre hospitalier universitaire Henri-Mondor, Université Paris Est, 51 Avenue du Maréchal de Lattre de Tassigny, Créteil 94010, France;3. Service d''Hépatologie, Centre hospitalier universitaire Henri-Mondor, Université Paris Est, 51 Avenue du Maréchal de Lattre de Tassigny, Créteil 94010, France;1. Department of Vascular Surgery, Université de Bordeaux, University Hospital of Bordeaux, Bordeaux, France;2. Department of Vascular Surgery, University Hospital of Poitiers, Poitiers, France;3. Department of Vascular Surgery, University Hospital of Padova, Padova, Italy;1. Department of Vascular Surgery Ospedale Civile S. Agostino-Estense, Azienda Ospedaliero- Universitaria di Modena, University of Modena and Reggio Emilia, Via Giardini, 1355, 41100 Baggiovara, Modena, Italy;2. Department of Cardiac, Thoracic, and Vascular Sciences, Vascular and Endovascular Surgery Unit, University of Padua, Padua, Italy |
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| Abstract: | PurposeTo evaluate the efficacy and safety of microwave (MW) ablation combined with percutaneous osteoplasty (POP) on painful extraspinal bone metastases.Materials and MethodsIn this retrospective study, 50 adult patients with 56 extraspinal bone metastasis lesions, who suffered from refractory moderate to severe pain, were treated with MW ablation and POP. Changes in quality of life were evaluated based on the Visual Analog Scale (VAS), daily morphine consumption, and the Oswestry Disability Index (ODI) before and immediately after the procedure and during follow-up times.ResultsTechnical success was achieved in all patients. Mean preoperative VAS score and morphine dose were 7.0 ± 2.6 (range, 3–10) and 66.7 ± 33.2 mg (range, 10–120 mg), respectively. Mean postoperative VAS scores and daily morphine doses were as follows: 1 day, 3.5 ± 2.1 and 36.1 ± 25.8 mg (P < .05); 1 week, 1.5 ± 1.7 and 12.2 ± 14.8 mg (P < .001); 1 month, 0.9 ± 1.4 and 5.7 ± 10.0 mg (P < .001); and 3 months, 0.6 ± 1.2 and 4.7 ± 8.4 mg (P < .001). A significant decrease in the ODI score was also observed (P < .05). Periprocedural death was not observed. A pathologic fracture occurred in 1 (2%) patient with femoral metastasis, and local infection was observed in 2 (4%) patients. Minor cement leakage occurred in 4 (8%) patients with no symptomatic or intra-articular extravasation. No local tumor progression occurred in patients with imaging follow-up.ConclusionsMW ablation combined with POP is an effective and safe treatment for painful extraspinal bone metastases, which can significantly relieve pain and improve quality of life. |
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