Toxoplasmosis as an Early Complication of Allogeneic Hematopoietic Cell Transplantation |
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| Institution: | 1. Assistance Publique-Hôpitaux de Paris, Henri Mondor Hospital, Department of Hematology and Cellular Therapy, Créteil, France;2. University Paris-Est Créteil (UPEC), Créteil, France;3. Parasitology Unit, Microbiology Department, Henri Mondor Hospital, Créteil, France;4. EA Dynamyc UPEC, Ecole Nationale Vétérinaire d''Alfort (ENVA), Faculté de Médecine de Créteil, Créteil, France |
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| Abstract: | Among 419 consecutive allogeneic hematopoietic cell transplant recipients, we observed 17 (4.0%) cases of toxoplasmosis at a median time of day 45 (range, 6 to 322) after transplant. Seven of these 17 cases occurred before day 30 after transplant. Because of the lack of PCR screening and trimethoprim-sulfamethoxazole prophylaxis before engraftment, the diagnosis of toxoplasmosis was late, and 5 of these 7 patients died. Analyzing these cases, early Toxoplasma blood PCR screening, starting from transplant, is crucial. |
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