Limited benefit of CT scans in tuberculosis contact tracing |
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| Institution: | 1. Research Institute of Tuberculosis, Japan;2. Department of Diagnostic Radiology, Fukujuji Hospital, Japan;3. Fukujuji Hospital, Japan;4. Respiratory Diseases Center, Fukujuji Hospital, Japan;1. Department of Radiation Oncology, Hospital de Câncer de Barretos, Barretos, São Paulo, Brazil;2. Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA;3. Department of Gynecology Oncology, Hospital de Câncer de Barretos, Barretos, São Paulo, Brazil;4. Department of Clinical Oncology, Hospital de Câncer de Barretos, Barretos, São Paulo, Brazil;5. Department of Radiology, Hospital de Câncer de Barretos, Barretos, São Paulo, Brazil;6. Department of Radiation Oncology, Cedars Sinai Medical Center, Los Angeles, CA;1. Servicio de Medicina Interna, Hospital Universitario de Guadalajara, Guadalajara, Spain;2. Servicio de Microbiología, Hospital Universitario de Guadalajara, Guadalajara, Spain;1. Department of Public Health and Family Medicine, University of Cape Town, South Africa;2. Centre for Lung Infection and Immunity, Department of Medicine, University of Cape Town, South Africa |
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| Abstract: | ObjectiveThe detection of abnormal findings on computed tomography (CT) scans of tuberculosis contacts combined with normal plain radiographs contributes to the early detection of tuberculosis. However, the benefit of the early detection of abnormalities for the prevention of active tuberculosis during follow-up requires evaluation.MethodWe conducted retrospective comparison of the existence of CT scans of tuberculosis contacts without findings of active tuberculosis on plain radiographs at a hospital in Japan. Results: Among 243 contacts without CT scans, five developed tuberculosis during follow-up. Among 229 contacts with CT scans, 24 were judged as targets of multi-drug therapy since their CT findings were suggestive of active tuberculosis at the time of the CT screening. Among 205 contacts judged as having latent tuberculous infection with CT screening, three developed tuberculosis diseases during follow-up. Conclusion: CT scans detected abnormal findings among contacts without abnormalities of plain radiographs but there were some contacts that developed tuberculosis diseases among those with contact investigation including CT scan. The value of CT is equivocal considering the balance of true treatment, overtreatment and harm of radiation. |
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| Keywords: | CT scan Contact tracing Tuberculosis |
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