Left Gastric Artery Embolization in Obese,Prediabetic Patients: A Pilot Study |
| |
| Institution: | 1. Department of Radiodiagnosis, Zagazig University, Zagazig 644631, Egypt;2. Department of Internal Medicine, Zagazig University, Zagazig 644631, Egypt;3. Department of Community and Family Medicine, Zagazig University, Zagazig 644631, Egypt;4. Department of Radiodiagnosis, Benha University, Benha, Egypt;5. Department of Radiodiagnosis, Cairo University, Cairo, Egypt;1. Department of Radiology and Biomedical Imaging, 505 Parnassus Avenue, M-361, University of California-San Francisco, CA 94143;2. Division of Gastroenterology/Hepatology, 505 Parnassus Avenue, M-361, University of California-San Francisco, CA 94143;1. University of Kentucky College of Medicine, Lexington, Kentucky;2. Division of Vascular and Interventional Radiology, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas;3. Department of Radiology, Houston Methodist Hospital, Houston, Texas;1. Vascular and Interventional Radiology Center, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital/The Johns Hopkins University, 1800 Orleans Street, Baltimore, MD 21287, United States;2. Department of Health, Behavior and Society, The Johns Hopkins Bloomberg School of Public Health, The Johns Hopkins University, 550 N. Broadway, Baltimore, MD 21205, United States;3. Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital/The Johns Hopkins University, 600 N. Wolfe Street, Baltimore, MD 21287, United States;4. Division of Interventional Radiology, Piedmont Radiology, 1984 Peachtree Road, Atlanta, GA 30309, United States |
| |
| Abstract: | PurposeTo evaluate the effect of left gastric artery embolization (LGAE) on glycated hemoglobin (HbA1c) in a prospective obese, prediabetic cohort.Materials and MethodsThis prospective pilot study included 10 obese, prediabetic patients (7 females and 3 males; mean age 37.5 ± 8.8 years; range 28–51 years) admitted to the Interventional Radiology Unit between January 2017 and June 2018 for LGAE for weight reduction. The main inclusion criteria were body mass index (BMI) >30 kg/m2 and HbA1c ranging from 5.7 to 6.4. Body weight, BMI, and HbA1c were assessed for each patient preprocedure and at 6 months postprocedure. Statistical analysis was performed using a paired sample t test.ResultsThe baseline mean body weight, BMI, and HbA1c were 107.4 ± 12.8 kg, 37.4 ± 3.3 kg/m2, and 6 ± 0.2, respectively. Concerning complications, no serious adverse events were detected. Six months after the procedure, the mean body weight and BMI significantly decreased to 98 ± 11.6 kg and 34.1 ± 3 kg/m2, respectively (P < .0001). A paired sample t test showed a significant reduction in HbA1c from pre- to postprocedure (6.1 ± 0.2 preprocedure vs 4.7 ± 0.6 postprocedure, P < .0001). The mean percent reductions in body weight, BMI, and HbA1c were 8.9% ± 1.2, 8.8% ± 1, and 21.4% ± 8.9, respectively. A statistically significant positive correlation was found between BMI and HbA1c after the procedure (r = 0.91, P = .0002).ConclusionsLGAE is well tolerated and leads to clinically significant decreases in weight and HbA1c in obese, prediabetic patients. |
| |
| Keywords: | AE"} {"#name":"keyword" "$":{"id":"kwrd0015"} "$$":[{"#name":"text" "_":"adverse event BMI"} {"#name":"keyword" "$":{"id":"kwrd0025"} "$$":[{"#name":"text" "_":"body mass index DSA"} {"#name":"keyword" "$":{"id":"kwrd0035"} "$$":[{"#name":"text" "_":"digital subtraction angiography HbA1c"} {"#name":"keyword" "$":{"id":"kwrd0045"} "$$":[{"#name":"text" "_":"glycated hemoglobin LGA"} {"#name":"keyword" "$":{"id":"kwrd0055"} "$$":[{"#name":"text" "_":"left gastric artery LGAE"} {"#name":"keyword" "$":{"id":"kwrd0065"} "$$":[{"#name":"text" "_":"left gastric artery embolization |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
