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Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope
Institution:1. Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA;2. Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50931 Cologne, Germany;3. German Center for Infection Research, partner site Bonn-Cologne, 50931 Cologne, Germany;4. Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA;5. Westridge High School, 324 Madeline Drive, Pasadena, CA 91105, USA;6. Vanderbilt Vaccine Center, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA;7. Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN 37232, USA;8. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA;9. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA;10. Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA;11. Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany;12. Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA
Abstract:
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  • Keywords:HIV-1  broadly neutralizing antibody  HIV-1 vaccine  immunotherapy  HIV-1 Env silent face  cryo-EM  humanized mice  glycan recognition  Env trimer
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