The feasibility of adjuvant interferon alpha-2b in children with high-risk melanoma |
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| Authors: | Navid Fariba Furman Wayne L Fleming Martin Rao Bhaskar N Kovach Sandra Billups Catherine A Cain Alvida M Amonette Rex Jenkins Jesse J Pappo Alberto S |
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| Affiliation: | Department of Hematology/Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA. fariba.navid@stjude.org |
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| Abstract: | BACKGROUND: It has been shown that induction high-dose interferon alpha-2b (IFN-alpha-2b) followed by maintenance therapy improves recurrence-free survival in adults with high-risk, resected melanoma. In this study, the feasibility and toxicity of this regimen were evaluated in newly diagnosed pediatric patients with Stage III melanoma involving regional lymph nodes. METHODS: Fifteen patients age
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