骨髓纤维化八例报告

本文报导8例骨髓纤维化,其中6例继发于慢性白血病,2例为原发性。男女各4例,年龄范围为23—67岁。1例原发性骨纤有苯接触史20余年,余7例均无明显毒物接触史。起病至确诊时间最短2个月,最长6年,8例病人血片中可见幼稚粒、红细胞及异形红细胞,骨髓象示:6例增生低下,2例增生活跃。8例经骨髓活检针病理证实纤维组织增生。1例急性骨纤死于感染,7例经用雄激素、强的松及输血等治疗,病情均有不同程度的改善而出院。

A REPORT OF EIGHT CASES OF MYELOFIBROSIS

This paper reports eight cases(4 males and 4 females) of myelofibrosis. Six of the were of CGL and two were of primary myelofibrosis. One of the primary cases had a history of contacting with benzene for more than 20 years, The sh- ortest and longest durations between the onset of the disease and the establishment of diagnosis were two months and six years respectively. The age of the patient ranged from 2B to67. The juvenile granulocytes, erythrocytes and poikilocytes were found in the blood films of all the eight cases. There was hypoplasia of bone-marrow in six eases and hyperplasia in two cases. Fibrosis was confirmed in all cases by biopsy of bone-marrow with aspirating needle. One case of acute myelofibrosis died of infection, while seven caess treated by testosterone, corticoid, etc, and by transfusion were discharged, with their conditions improved.