| 血清胸腺因子抗EAC瘤、H22瘤、W256瘤作用的初探 |
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| 引用本文： | 张长平,乐嘉静,李湛君,徐康森. 血清胸腺因子抗EAC瘤、H22瘤、W256瘤作用的初探[J]. 中国临床药理学与治疗学, 2007, 12(6): 668-671 |
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| 作者姓名： | 张长平 乐嘉静 李湛君 徐康森 |
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| 作者单位： | 1. 南京医科大学,南京,210029,江苏
2. 中国药品生物制品检定所,北京,100050 |
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| 摘 要： | 目的：观察血清胸腺因子（FTS）对荷瘤小鼠的抑瘤作用。方法：荷EAC瘤小鼠、荷H22瘤小鼠、荷W256瘤大鼠分别皮下注射给予不同剂量的FTS,测定其生命延长率和抑瘤率,并测定T细胞增殖能力、迟发型超敏反应等免疫指标。结果：荷EAC、H22瘤小鼠注射FTS0.25、0.13mg/kg剂量后生命延长率或抑瘤率均大于30%,生存天数和瘤重与阴性对照组（NS）比较有统计学差异（P〈0.01）;荷W256瘤大鼠FTS各组瘤重与NS组比较均有统计学差异（P〈0.01）,抑瘤率均大于30%。另外,伴刀豆球蛋白A（ConA）刺激后0.016mg/mL处刺激指数最大。迟发型超敏反应亦呈现阳性结果。结论：FTS对EAC瘤、H22瘤、W256瘤均具有一定的抑制作用。
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| 关 键 词： | 血清胸腺因子 抑瘤率 生命延长率 免疫增强 |
| 文章编号： | 1009-2501（2007）06-0668-04 |
| 修稿时间： | 2007-03-102007-05-16 |
Initial study on anticancer effect of serum thymic factor |
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| ZHANG Chang-ping,LE Jia-jing,LI Zhan-jun,XU Kang-sen. Initial study on anticancer effect of serum thymic factor[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(6): 668-671 |
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| Authors: | ZHANG Chang-ping LE Jia-jing LI Zhan-jun XU Kang-sen |
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| Affiliation: | Nanjing Medical University, Nanjing 210029, Jiangsu, China; 2National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050, China |
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| Abstract: | AIM: To study the inhibitory effect of serum thymic factor (FTS) on cancer cells. METHODS: Bearing cancer mice, rats were administrated with different dosages of FTS. Life extension rate and inhibitory rate were determined. Stimulation index (SI) and delayed hypersensitivity were observed, too. RESULTS: Life extension rate or inhibitory rate in mice exceeded 30% in 0.25 mg/kg group and 0.13 mg/kg group, and those parameters in rats also exceeded 30% in FTS three groups. After Con-A stimulation, SI achieved maximum at 0.016 mg/mL. Delayed hypersensitivity also showed positive results. CONCLUSION: FTS has significant inhibitory effect on the growth of EAC, H22 and W256 cancer cells. |
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| Keywords: | serum thymic factor inhibitory rate life extension rate immunological enhancement |
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