主动靶向脂质体研究进展

目的 介绍主动靶向脂质体最新研究进展。方法 查阅近年来国内外相关文献,对主动靶向脂质体的表面修饰、配体选择及应用进行进行总结和归纳。结果 主动靶向脂质体的表面修饰有三种方法：作为组份直接制备；键合到脂质体表面；后插入法。主动靶向脂质体可以将药物传递到靶组织、靶向细胞或靶细胞器,提高药物的生物利用度,而不增加对正常组织或细胞的毒性,是近年研究最为广泛的主动靶向给药系统。结论 主动靶向脂质体是一种非常有前途的给药系统。

Advances in Active Targeting Liposomes

ABSTRACT: OBJECTIVE To introduce the latest researches about active targeting liposomes. METHODS Review the strategies of adsorbing ligands onto the vector surface, the selection of targeted ligands and the application of active targeting liposomes through searching and summarizing relevant literatures. RESULTS There are three strategies of adsorbing ligands onto the vector surface: addition of ligands as components during the preparation liposomes, direct coupling method, post insertion method. Active targeting of liposomes can deliver the cargo to target cells, tissues and even the intracellular localization, which can improve the drug bioavailability and produced no increase in toxicity towards normal tissue or cells. The drug-delivery system has become one of the most widely studied of targeting drug-deliver systems in recent years. CONCLUSION The active targeting liposomes is a very promising drug delivery system.