天然药物材料白及胶制备生物支架材料的实验研究

目的 探索采用中药天然成分制备多孔支架材料用于骨缺损修复生物材料的可行性,考察用于骨骼组织修复的白及胶支架材料的制备方法及其性能.方法 从中药材白及中提取白及胶并精制,然后进行醛基化反应,与其他赋形剂共混、交联,冷冻干燥得到支架材料.结果 利用水提醇沉法及酶法精制纯化能得到较高纯度的白及胶;经氧化后发生Schiff碱缩合反应,形成良好的网状结构,冷冻干燥制得多孔支架材料.结论 以白及胶为主要原料制备的生物支架材料,各项性能表征符合多孔支架材料要求.

Study on preparation of natural medicine gum-bletilla scaffolds

Objective To explore the feasibility of natural constituents in Chinese materia medica used for the preparation of porous scaffold material as bone repair biomaterials and for the tissue regeneration and to study the preparation method and the properties of gum-bletilla scaffolds. Methods Gum-bletilla was extracted from Bletilla Rhizoma, then purified, hydroformylated, mixed with other excipient, cross-linked, and lyophilized to get scaffolds. Results High-purity standard gum-bletilla could be obtained by water extraction, alcohol-precipitation, and enzymatic purification. After oxidation, the gum-bletilla had Schiff base condensation to form reticular conformation, which was made into porous materials by freeze-drying. Conclusion The scaffolds could be made of gum bletilla, which conforms to the requirements.