| 罗红霉素晶型分析及与溶解速率、溶出度的关系 |
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| 引用本文： | 王建,曾红霞,陈悦.罗红霉素晶型分析及与溶解速率、溶出度的关系[J].中国现代应用药学,2013,30(10):1094-1097. |
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| 作者姓名： | 王建 曾红霞 陈悦 |
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| 作者单位： | 浙江省食品药品检验研究院,浙江工业大学,浙江省食品药品检验研究院 |
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| 基金项目： | 2012年国家药品评价性抽验项目 |
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| 摘 要： | 目的 对罗红霉素的晶型进行分析,并探讨不同晶型对罗红霉素溶解速率、溶出度的影响。方法 晶型分析采用x射线粉末衍射法和红外光谱法,溶解速率和溶出度测定采用转篮法、转速为100r.min-1。结果 3种罗红霉素的结晶为3种不同的晶型,不同晶型的罗红霉素溶解速率和溶出度有一定差异。结论 为罗红霉素的质量控制提供了科学依据。
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| 关 键 词： | 罗红霉素 晶型 溶解速率 溶出度 x射线粉末衍射法 红外光谱法 |
| 收稿时间： | 3/1/2013 12:00:00 AM |
| 修稿时间： | 2013/5/20 0:00:00 |
Relationship of Roxithromycin Crystal Types, Dissolution Rates and Dissolution |
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| WANG Jian,ZENG Hongxia and CHEN Yue.Relationship of Roxithromycin Crystal Types, Dissolution Rates and Dissolution[J].The Chinese Journal of Modern Applied Pharmacy,2013,30(10):1094-1097. |
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| Authors: | WANG Jian ZENG Hongxia and CHEN Yue |
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| Institution: | Zhejiang Institute for food and Drug Control,Zhejiang University of Technology,Zhejiang Institute for food and Drug Control |
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| Abstract: | ABSTRACT: OBJECTIVE To study crystal type of roxithromycin, and the relationship of roxithromycin crystal type and its dissolution rate and dissolution. METHODS X ray powder diffraction and infrared spectroscopy were used in the analysis of crystal type. The dissolutive Apparatus 1 was used with 100 rpm. RESULTS The result showed that three roxithromycin crystal were different crystal type, and the dissolution rate and dissolution of different crystal type had some difference. CONCLUSION The study provide a scientific basis for quality control of roxithromycin. |
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| Keywords: | roxithromycin crystal type dissolution rate dissolution X ray powder diffraction X ray powder diffraction infrared spectroscopy |
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