| 寻常型银屑病皮损中磷酸化信号转导和转录激活因子-3与白介素-17的表达及意义 |
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| 引用本文： | 卢井发,罗迪青.寻常型银屑病皮损中磷酸化信号转导和转录激活因子-3与白介素-17的表达及意义[J].中国医药导报,2012,9(28):27-29. |
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| 作者姓名： | 卢井发 罗迪青 |
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| 作者单位： | 中山大学附属第一医院黄埔院区皮肤科,广东广州,510700 |
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| 摘 要： |
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| 关 键 词： | 银屑病 信号转导和转录激活因子-3 白介素-17 |
Expression and significance of P-Stat3 and IL-17 in psoriasis vulgaris |
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| LU Jingfa
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LUO Oiqing.Expression and significance of P-Stat3 and IL-17 in psoriasis vulgaris[J].China Medical Herald,2012,9(28):27-29. |
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| Authors: | LU Jingfa LUO Oiqing |
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| Institution: | Department of Dermatology, Huangpu Hospital of the First Hospital Affiliated to Sun Yat-sen University, Guangdong Province, Guangzhou 510700, China |
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| Abstract: | Objective To study the expression and significance of P-Stat3 and IL-17 in psoriasis vulgaris. Methods 23 patients with psoriasis vulgaris （experiment group） and 14 healthy individuals （control group） were studied. The expression of P-Stat3 and IL-17 in psoriatic lesions tissue and healthy controllers were determined by immunohistochemistry. Results The levels of P-Stat3 and IL-17 in the psoriatic lesions were significantly higher than those of control group, respectively （Z = -5.043 and -4.324, all P 〈 0.01）; and both of them were positively correlated with PASI, respectively （rs = 0.713 and 0.797, all P 〈 0.001）. The levels of P-Stat3 in the psoriatic lesions were positively correlated with those of IL-17 （rs = 0.762, P 〈 0.001）. Conclusion In patients with psoriasis vulgaris, there are increases of the expression of P-Stat3 and IL- 17 in the poriatic lesions, which are positively correlated with the disease severity. |
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| Keywords: | Psoriasis P-Stat3 IL-17 |
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