| 凝固酶阴性葡萄球菌致新生儿败血症的耐药性分析 |
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| 引用本文： | 彭敬红,吕军,吴均竹,张珍,杨宏伟,娄国平. 凝固酶阴性葡萄球菌致新生儿败血症的耐药性分析[J]. 中华医院感染学杂志, 2011, 21(5): 1034-1036 |
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| 作者姓名： | 彭敬红 吕军 吴均竹 张珍 杨宏伟 娄国平 |
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| 作者单位： | 湖北医药学院附属太和医院检验部,湖北,十堰,442000 |
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| 摘 要： | 目的探讨凝固酶阴性葡萄球菌(CNS)致新生儿败血症的病原学及耐药性现状,为临床诊断与治疗提供实验室依据。方法对139例CNS致新生儿败血症血培养的病原学及耐药性进行回顾性分析。结果 218份血培养细菌阳性标本中,共分离出CNS 139株,占63.8%;耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)70株,检出率为50.4%,MRCNS多药耐药现象严重,对磺胺甲噁唑/甲氧苄啶的耐药率高达92.9%,对环丙沙星、庆大霉素、克林霉素的耐药率在57.1%~68.6%,与MSCNS相比差异有统计学意义(P<0.01);MRCNS与MSCNS对红霉素和青霉素的耐药率均>80.0%,MRCNS对米诺环素的耐药率较低,为4.3%,未见耐万古霉素菌株。结论 CNS已成为新生儿血液感染第1位的病原菌,检出率高且呈多药耐药;万古霉素仍是MRCNS的最佳药物;临床应根据血培养和药敏结果选用敏感抗菌药物,以减少耐药菌株产生,提高治疗效果。
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| 关 键 词： | 新生儿败血症 凝固酶阴性葡萄球菌 耐药性 |
Drug resistance of coagulase negative staphylococcus in neonates with septicemia |
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| PENG Jing-hong,L Jun,WU Jun-zhu,ZHANG Zhen,YANG Hong-wei,LOU Guo-ping. Drug resistance of coagulase negative staphylococcus in neonates with septicemia[J]. Chinese Journal of Nosocomiology, 2011, 21(5): 1034-1036 |
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| Authors: | PENG Jing-hong L Jun WU Jun-zhu ZHANG Zhen YANG Hong-wei LOU Guo-ping |
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| Affiliation: | PENG Jing-hong,L(U) Jun,WU Jun-zhu,ZHANG Zhen,YANG Hong-wei,LOU Guo-ping |
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| Abstract: | OBJECTIVE To investigate the etiology and drug resistance of neonatal septicemia caused by coagulase-negative Staphylococcus(CNS),to provide basis for clinical diagnosis and therapy.METHODS Totally 139 cases of CNS neonatal septicemia caused by the pathogen in blood culture and drug resistance were analyzed retrospectively.RESULTS A total of 139 strains of coagulase negative Staphylococcus were isolated from 218 patients with positive blood culture samples of bacteria,with the detectin rate 63.8%.Among whic... |
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| Keywords: | Neonatal septicemia Coagulase-negative Staphylococcus Drug resistance |
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