| 尼莫地平鼻用冻干脂质体的小鼠药效学及纤毛毒性 |
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| 引用本文： | 李茗,毕殿洲. 尼莫地平鼻用冻干脂质体的小鼠药效学及纤毛毒性[J]. 中国医药工业杂志, 2006, 37(9): 614-616 |
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| 作者姓名： | 李茗 毕殿洲 |
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| 作者单位： | 1. 北京市海淀区药品检验所,北京,100083
2. 沈阳药科大学药学院,辽宁,沈阳,110016 |
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| 基金项目： | 国家高技术研究发展计划(863计划) |
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| 摘 要： | 采用小鼠模型，验证尼莫地平脂质体鼻黏膜给药的药效学。结果表明，对小鼠抗脑缺氧、抗急性脑缺血及抗急性脑栓塞形成等均有显著的保护作用，其药效与腹腔注射尼莫地平溶液接近，显著优于灌胃给药。另采用蟾蜍上颚纤毛模型，考察了空白脂质体及含药脂质体的纤毛毒性，结果表明尼莫地平脂质体对纤毛运动和形态有一定影响。
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| 关 键 词： | 尼莫地平 脂质体 药效学 纤毛毒性 |
| 文章编号： | 1001-8255（2006）09-0614-03 |
| 收稿时间： | 2005-11-15 |
| 修稿时间： | 2005-11-15 |
Pharmacodynamics in Mice and Nasal Ciliary Toxicity of Freeze-dried Nimodipine Liposomes for Intranasal Administration |
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| LI Ming,BI Dian-Zhou. Pharmacodynamics in Mice and Nasal Ciliary Toxicity of Freeze-dried Nimodipine Liposomes for Intranasal Administration[J]. , 2006, 37(9): 614-616 |
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| Authors: | LI Ming BI Dian-Zhou |
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| Affiliation: | 1. Hai Dian District Institute for Drug Control, Beijing 100083; 2. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016 |
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| Abstract: | The pharmacodynamics of nimodipine liposomes following intranasal administration were evaluated in mice using brain hypoxia model, complete brain ischemia model and cerebral thrombus model respectively. Nimodipine liposomes could effectively protect the brain against damage, and were comparable to that after ip nimodipine injection but significantly better than that after ig administration. In addition, the potential toxicity of nimodipine liposomes to nasal mucosa was evaluated using a toad model, and the toxicity on the ciliary movement and morphology was observed. |
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| Keywords: | nimodipine liposome pharmacodynamics nasal ciliary toxicity |
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