| 阿霉素脂质体犬肝动脉栓塞后阿霉素体内特征 |
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| 引用本文： | 朴相浩,吴道澄.阿霉素脂质体犬肝动脉栓塞后阿霉素体内特征[J].第四军医大学学报,1996,17(1):42-45. |
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| 作者姓名： | 朴相浩 吴道澄 |
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| 作者单位： | 第四军医大学唐都医院放射科，第四军医大学化学教研室，第四军医大学西京医院药剂科 |
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| 摘 要： | 目的：研究阿霉素脂质体－碘油犬肝动脉栓塞后的体内靶向性特征和药代动力学，方法：用高效液色相色谱法（ＨＰＬＣ）测定犬血浆和肝组织中阿霉素的浓度。结果：阿霉素脂质体－碘油栓塞组犬血浆阿霉素浓度显著低于阿霉素溶液灌注组（Ｐ〈０．０１）和阿霉素－碘油栓塞组（Ｐ〈０．０５），而其血浆阿霉素消除半衰期和肝组织中阿霉素中浓度与后两组比则显著增加（Ｐ〈０．０１，Ｐ〈０．０５）。结论：阿霉素脂质体与碘油混合肝动脉栓
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| 关 键 词： | 阿霉素 脂质体 制剂 肝动脉 栓塞疗法 |
The in vivo characteristics of adriamycin after embolization of the hepatic artery with adriamycin liposome in dogs |
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| Piao Xianghao ,Wang Zhimin ,Wu Daocheng ,Zhang Guomin ,Xu Shandan ,Wen Aidong.The in vivo characteristics of adriamycin after embolization of the hepatic artery with adriamycin liposome in dogs[J].Journal of the Fourth Military Medical University,1996,17(1):42-45. |
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| Authors: | Piao Xianghao Wang Zhimin Wu Daocheng Zhang Guomin Xu Shandan Wen Aidong |
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| Institution: | Piao Xianghao 1,Wang Zhimin 1,Wu Daocheng 2,Zhang Guomin 1,Xu Shandan 1,Wen Aidong 3 1Department of Radiology,Tangdu Hospital,Fourth Military Medical University,Xi'an 710038 2Department of Chemistry,Fourth Military Medical Universit |
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| Abstract: | Objective: The targeting characteristics and pharmacokinetics of adriamycin (ADM) were studied in vivo after embolization of the hepatic artery with the mixture of liposome of adriamycin (LADM) and lipiodol in dogs. Methods: ADM concentrations in plasma and liver of dog were determined using HPLC. Results: Compared with those in dogs with ADM being infused into hepatic artery and in animals with hepatic arterial embolization using ADM lipiodol mixture, plasma ADM concentration in dogs after embolization of the hepatic artery with the mixture of LADM and lipiodol decreased significantly ( P <0.01, P <0.05), while ADM concentration in livers and its half life increased significantly ( P <0.01, P <0.05). Conclusion: Embolization by LADM mixed with lipiodol can improve ADM's targeting to the liver and increase its half life. |
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| Keywords: | adriamycin liposome hepatic arterial embolization pharmacokinetics HPLC |
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