Ki67在乳腺癌组织中表达及其与C—erbB-2、ER、PR、P53基因的关系

目的：探讨Ki67基因在乳腺癌组织中的表达及其与C—erbB-2、ER、PR、P53基因的相关关系。方法：用免疫组化方法检测133例乳腺癌组织中Ki67、C—erbB-2、ER、PR、P53的表达。结果：Ki67在乳腺癌组织中总阳性率为78．2％，Ki67表达与乳腺癌肿瘤大小和I临床分期有显著相关性（P〈0．05），与患者的年龄、腋窝淋巴结转移无显著相关性（P〉0．05）；乳腺癌组织的Ki67表达强度与C—erbB-2、1353强度的表达呈正相关（1分别为0．172、0．280，P〈0．05），与ER强度的表达呈负相关（γ为-0．193，P〈0．05），与PR表达强度无显著相关性（γ为-0．007，P〉0．05）。结论：Ki67表达与乳腺癌发生、发展有关，是一个不良预后因素。

The expression of Ki67 in the breast cancer tissue and its correlation with C -erbB -2,ER.PR and P53

Objective：To investigate the expression of Ki67 in the breast cancer tissue and its correlation with C - erbB - 2, ER,PR and P53. Methods：The expression of Ki67, C -erbB -2, ER,PR and P53 in 133 cases of breast cancer were assessed by immunohistochemistry. Results： The result indicates that the total positive rate of Ki67 in breast cancer issue is 78.2%. The expression of Ki67 has significant correlation with tumor size and clinical stages（ P 〈 0.05 ） , but not with the patients＇age or axillary lymph node metastasis（P 〉0.05）. The expression strength of Ki67 has positive correlation with that of C -erbB -2 and P53 （γ0. 172 and 0.280 respectively, P 〈 0.05 ） , and it negatively correlates with the expression strength of ER（ γ-0. 193, P 〈 0.05 ）. And there is no significant correlation between the expression strength of Ki67 and that of PR （ γ - 0.007, P 〉 0.05）. Conclusions ： The expression of ki67 is related with the occurrence and progression of breast cancer. And it can determine the progrosis of breast cancer.