盐酸阿洛司琼片剂的研制

研制盐酸阿洛司琼片剂，建立了紫外分光光度法测定片剂的含量，在0.1mol/L盐酸溶液中测定波长为295nm，标准曲线A=0.0279C-0.0012，相关系数r=0.9999。加样回收率分别为99.01%,99.48%,100.63%,RSD均小于1%，三批片剂的含量分别为99.32%,100.04%,99.70%。含量均匀度分别为6.612,6.97,5.05。日间和日内误差分别为0.88%,0.63%。三批片剂30min的溶出度高于90%。

Preparation and study of Alosetron hydrochloride tablets

Alosetron hydrochloride tablets were prepared and studied. The content of tablets was determined by method of UV spectrum. The wavelength was defined at 295 nm in 0.1 mol/L hydrochloride solution. The equation of standard curve was expressed as A=0.0279C-0.0012, r=0.9999. The contents of three batches were 99.32%, 100.04%,99.70%, respectively. The evenness was 6.61, 6.97, 5.05. Recovery was 99.01% ,99.48% , 100.63%, respectively. RSD was less than 1%. The SD for within-day and between-days is 0.88%, 0.63%. Average dissolution rates of three batches were greater than 90% at 30 minutes.