| 心肌缺血预适应家兔血浆内皮素及血清一氧化氮水平变化的意义 |
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| 引用本文： | 张三强,潘苗,王朝清,赵国安. 心肌缺血预适应家兔血浆内皮素及血清一氧化氮水平变化的意义[J]. 实用儿科临床杂志, 2010, 0(7) |
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| 作者姓名： | 张三强 潘苗 王朝清 赵国安 |
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| 作者单位： | 新乡医学院第二附属医院心内科;新乡医学院第二附属医院临床教研室;新乡医学院第三附属医院心内科; |
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| 基金项目： | 河南省教育厅资助课题(98320027) |
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| 摘 要： | 目的探讨心肌缺血预适应家兔血浆内皮素(ET)及血清一氧化氮(NO)水平的变化,探讨其在心肌缺血预适应过程中的作用。方法16只新西兰大耳白兔随机分为2组。缺血再灌注组(I/R组):结扎其冠状动脉左室支40min后再灌注120min;缺血预适应组(IP组):先予缺血预适应的过程,结扎冠状动脉左室支5min,放松冠脉血管后再灌注5min,反复操作3次,再按照I/R组进行操作。实验开始前取血测定血清CK、LDH、NO及血浆ET水平,2组动物均在结扎左室支40min、再灌注120min复测NO及ET水平,观察NO和ET变化。结果IP组阻断40min及再灌注120min血浆ET水平及LDH升高低于I/R组,二组比较差异有统计学意义(Pa<0.01),血清NO水平升高多于I/R组,二组比较差异有统计学意义(P<0.01)。IP组再灌注120min,CK水平升高于I/R组,心肌损伤程度小于I/R组。结论心肌缺血预适应家兔NO及ET水平发生明显变化,缺血预适应过程中NO水平升高增强了心肌对缺血的耐受性,ET水平降低减少了心肌缺血过程中其对心肌的损伤。
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| 关 键 词： | 心肌缺血再灌注 缺血预适应 一氧化氮 内皮素 兔 |
Significance of Changes of Endothelin in Plasma and Nitrogen Monoxidum in Serum on Myocardial Cell during Ischemic Preconditioning in Rabbits |
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| ZHANG San-qiang,PAN Miao,WANG Chao-qing,ZHAO Guo-an. Significance of Changes of Endothelin in Plasma and Nitrogen Monoxidum in Serum on Myocardial Cell during Ischemic Preconditioning in Rabbits[J]. Journal of Applied Clinical Pediatrics, 2010, 0(7) |
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| Authors: | ZHANG San-qiang PAN Miao WANG Chao-qing ZHAO Guo-an |
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| Affiliation: | ZHANG San-qiang1,PAN Miao2,WANG Chao-qing1,ZHAO Guo-an3(1.Department of Cardiology,the Second Affiliated Hospital of Xinxiang Medical University,Xinxiang 453002,Henan Province,China,2.Department of Clinical Teaching , Research,3.Department of Cardiology,the Third Affiliated Hospital of Xinxiang Medical University,Xinxiang 453003,China) |
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| Abstract: | Objective To investigate the changes and effects of endothelin (ET) in plasma and nitrogen monoxidum(NO) in serum during ischemic preconditioning in rabbits.Methods Sixteen white New Zealand rabbits were randomly divided into 2 groups.Ischemic reperfusion(I/R) group:rabbits underwent 40 minutes of occlusion of the left circumflex coronary artery,and 120 minutes of reperfusion.Ischemic preconditioning(IP) group:rabbits underwent 3 cycles of 5 minutes of occlusion and reperfusion,followed by 40 minutes of occ... |
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| Keywords: | ischemic reperfusion ischemic preconditioning nitrogen monoxidum endothelin rabbit |
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