| 男性无精子症和严重少精子症患者SPGY1基因微缺失的检测 |
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| 引用本文： | 杨艳红,姚元庆,苏明权,高萍,王晓红,尹国武,李东红.男性无精子症和严重少精子症患者SPGY1基因微缺失的检测[J].第四军医大学学报,2003,24(9):859-861. |
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| 作者姓名： | 杨艳红 姚元庆 苏明权 高萍 王晓红 尹国武 李东红 |
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| 作者单位： | 1. 第四军医大学唐都医院妇产科,陕西,西安,710038
2. 第四军医大学西京医院检验科,陕西,西安,710033 |
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| 摘 要： | 目的：研究Y染色体上无精子因子(AZoospermia Factor,AZF)的缺失与无精症和严重少精子症的关系．方法：应用PCR方法检测了40例正常男子、42例无精子症和31例严重少精子症男子基因组DNA中AZFc区的SPGYl(SPer-matogenesis Gene locus on the Y)基因．结果：无精子症患中6例SPGYl基因缺失(6／42)；严重少精子症患中5例SP—GYl基因缺失(5／31)；73例男性不育患AZFc区SPGYl基因缺失率为15％(11／73)．40例已生育的正常男性对照均未检测到SPGYl基因的缺失．结论：Y染色体SPGYl基因缺失可能是造成男性不育的原因之一，有必要对男性不育患进行Y染色体基因缺失的检测。
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| 关 键 词： | Y染色体 男性不育 无精子因子 基因缺失 |
| 文章编号： | 1000-2790(2003)09-0859-03 |
| 修稿时间： | 2002年7月19日 |
Investigation of SPGY1 microdeletion in patients with azoospermia and severe oligozoospermia |
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| YANG Yan Hong ,YAO Yuan Qing ,SU Ming Quan ,GAO Ping ,WANG Xiao Hong ,YIN Guo Wu ,LI Dong Hong.Investigation of SPGY1 microdeletion in patients with azoospermia and severe oligozoospermia[J].Journal of the Fourth Military Medical University,2003,24(9):859-861. |
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| Authors: | YANG Yan Hong YAO Yuan Qing SU Ming Quan GAO Ping WANG Xiao Hong YIN Guo Wu LI Dong Hong |
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| Institution: | YANG Yan Hong 1,YAO Yuan Qing 1,SU Ming Quan 2,GAO Ping 1,WANG Xiao Hong 1,YIN Guo Wu 1,LI Dong Hong 1 1Department of Obstetrics & Gynaecology,Tangdu Hospital,Fourth Military Medical University,Xi'an 710038,China,2Department of Clinical Laboratories,Xijing Hospital,Fourth Military Medical University,Xi'an 710033,China |
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| Abstract: | AIM: To investigate the microdeletion of spermatogenesis gene locus on the Y (SPGY1) in patients with azoospermia and severe oligozoospermia. METHODS: SPGY1 in AZFc was detected in 40 normal males, 42 azoospermia patients and 31 severe oligozoospermia patients by polymerase chain reaction (PCR). RESULTS: Six patients with azoospermia had SPGY1 microdeletion. The rate of microdeletion was 14% (6/42). Five microdeletion cases were found in severe oligozoospermia patients. Microdeletion rate was 15% (5/31). The average rate of SPGY1 deletion in patients with azoospermia and severe oligozoospermia was 15% (11/73). No SPGY1 deletion was found in the forty fertile males. CONCLUSION: Microdeletion of SPGY1 in AZFc of Y chromosome may be one of the causes account for male infertility. It is necessary to detect the Y chromosome microdeletion should be detected in infertile males. |
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| Keywords: | Y chromosome male infertility azoospermia factor gene deletion |
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