| 复方感冒透皮贴剂经皮肤给药的安全性评价研究 |
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| 引用本文： | 孙晓迪,张京,孙世光,史琪荣,闫荟. 复方感冒透皮贴剂经皮肤给药的安全性评价研究[J]. 中医药导报, 2012, 18(2): 74-76 |
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| 作者姓名： | 孙晓迪 张京 孙世光 史琪荣 闫荟 |
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| 作者单位： | 北京军区总医院,北京,100700 |
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| 摘 要： | 目的:考察复方感冒透皮贴剂经皮肤给药的安全性。方法:通过对健康豚鼠皮肤急性毒性试验、皮肤刺激性试验及皮肤过敏性试验,观察复方感冒透皮贴剂经皮肤用药的急性毒性、刺激性和敏感性。结果:复方感冒透皮贴剂对豚鼠完整皮肤和破损皮肤均无急性毒性、刺激性和致敏性。结论:本实验所用复方感冒透皮贴剂经皮肤给药安全。
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| 关 键 词： | 透皮贴剂 急性毒性 皮肤刺激性 皮肤过敏性 |
Enepidermic Reliability of Compound Cold Transdermal Patch |
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| Sun Xiaodi,Zhang Jing,Sun Shiguang,Shi Qirong,Yan Hui. Enepidermic Reliability of Compound Cold Transdermal Patch[J]. GUIDING JOURNAL OF TCM, 2012, 18(2): 74-76 |
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| Authors: | Sun Xiaodi Zhang Jing Sun Shiguang Shi Qirong Yan Hui |
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| Affiliation: | (corresponding author)(Department of pharmacy,general hospital of beijing military region,Beijing 100700) |
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| Abstract: | Obiective: To investigate the safety of compound cold transdermal patch through the skin.Methods: The aim of this research was to survey acute toxicity,irritation and hypersensitivity of compound cold transdermal patch on animal skin through skin acute toxicity,skin irritation and skin hypersensitiviy test in healthy guinea pigs.Results: The result showed that the compound cold transdermal patch had no acute toxicity,irritation and hypersensitivity on integrated and worn skin of guinea pigs.Conclusions: The experiment indicated that it is safe to administrate the compound cold transdermal patch via skin. |
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| Keywords: | Transdermal patch Acute toxicity Skin irritation Skin hypersensitiviy |
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