螺内酯对2型糖尿病大鼠24小时尿白蛋白排泄率的影响 |
| |
引用本文: | 周香然,韩刚,孙侃,常向云,李军. 螺内酯对2型糖尿病大鼠24小时尿白蛋白排泄率的影响[J]. 医学临床研究, 2012, 29(1): 57-60 |
| |
作者姓名: | 周香然 韩刚 孙侃 常向云 李军 |
| |
作者单位: | 石河子大学医学院,新疆,石河子,832000 |
| |
摘 要: | [目的]观察螺内酯对2型糖尿病大鼠肾功能的影响.[方法]48只大鼠用高脂高糖饲料喂养2个月后,腹腔注射 30 mg/kg链脲佐菌素制备糖尿病大鼠模型.随机分为糖尿病组 (DM组,n =24)、螺内酯治疗组(R组,n =24),另选同批普通饲养大鼠15只作为正常对照组 (C组,n=15),检测第16周末血清中血糖(FBG)、糖化血红蛋白(HbA1c)、钾(K+)、24 h尿白蛋白排泄率(UAER)、尿素氮(U-BUN)、肌酐(Cr)、甘油三酯(TG).并用He染色的方法观察16周后大鼠肾脏的病理学变化.[结果]第16周的血糖水平DM组和 R组相近,无显著差别( P >0.05),但DM组和 R组的血糖水平均显著高于A组( P <0.01);UAER水平DM组和 R组显著高于C组( P <0.01),且R组UAER水平显著低于DM组( P <0.01).[结论] 螺内酯能通过降低糖尿病大鼠UAER,改善糖尿病大鼠的肾功能从而发挥保护肾脏的作用.
|
关 键 词: | 糖尿病,非胰岛素依赖型/药物疗法 螺内酯/药理学 白蛋白尿 |
Effect of Spironolactone on 24h Urine Albumin Excretion Rate in Rats with Type 2 Diabetes Mellitus |
| |
Affiliation: | ZHOU Xiang-ran, HAN Gang, SUN Kang, et al ( Medical College of Shihezi University, Xinjiang 832000, China ) |
| |
Abstract: | [Objective] To observe the effect of spironolactone on renal function in rats with type 2 diabetes mellitus (T2DM). [Methods]The rat model of T2DM was prepared by intraperitoneal injection of streptozocin(STZ) 30mg/kg after feeding high-sugar and fat diet for 2 months. The rats were assigned to diabetic group(group DM, n :24) and spi- ronolactone treatment group(group R, n = 24). Other 15 rats fed with normal diet were selected as normal control group (group C, n = 15). Blood glucose(FBG), glycosylated hemoglobin(HbAlc), kalium(K+), 24h urine albumin excretion rate(UAER), urea nitrogen(U-BUN), creatinine(Cr) and triglyceride(TG) at the end of 16th week were detected. HE staining was used to observe the pathological change of kidney in rats after 16 weeks. [Results] At the end of 16th week, BG level in group DM was similar to that in group R, and there was no significant difference( P 〉0.05). BG level in group DM and group R were significantly higher than that in group C( P 〈0.01). UAER level in group DM and group R were significantly higher than that in group C( P〈0. 001), but UAER level in group R was significantly lower than that in group DM( P〈0.01). [Conclusion] Spironolactone may play the protective role for kidney through decreasing UAER level and improving renal function in diabetic rats. |
| |
Keywords: | Diabetes mellitus,non-insulin-dependent/DT spironolactone/PD albuminuria |
本文献已被 维普 万方数据 等数据库收录! |
|