肝病相关自身抗体检测在自身免疫性肝病诊断中的价值研究

目的 自身免疫性肝病临床流行病学调查,观察各肝病患者中自身抗体检测的阳性率,自身免疫性肝病检测的阳性率；探讨自身抗体检测对自身免疫性肝病的诊断价值.方法 对2007年10月至2010年10月2 714份自身抗体检验结果进行回顾性分析,并对自身抗体阳性病例的查阅临床资料.结果 2 714份血清中自身抗体阳性472例,阳性率17.4％,抗核抗体(ANA)阳性418例,阳性率15.4％,抗线粒体抗体(AMA)阳性124例,阳性率4.57％,抗平滑肌抗体阳性91例,阳性率3.35％,抗肝肾微粒体抗体( LKM)阳性16例,阳性率0.59％,抗肝细胞膜抗体阳性(LMA)8例,阳性率0.29％,抗肝细胞溶质抗原1型抗体(LC-1)阳性5例,阳性率0.18％,抗肝特异性脂蛋白抗体(LSP)阳性3例,阳性率0.11％,2 914例送检标本中诊断为AIH 59例,阳性率为2.17％,诊断为PBC 61例,阳性率为2.24％.自身抗体阳性患者74.57％诊断为病毒性肝炎及相关疾病.结论 自身抗体检测是诊断自身免疫性肝病的必要条件,但这些自身抗体也可见病毒性肝炎,药物性肝炎及其他疾病.

The diagnostic value of detection of liver-related autoantibodies in autoimmune liver diseases

Objective To investigate the positive rate of detection of autoantibodies in patients with different liver diseases and in patients with autoimmune liver diseases by clinical epidemiological survey in order to explore the diagnostic value of detection of autoantibodies in autoimmune liver diseases. Methods The detection results for autoantibody in 2,714 specimens from October 2008 to October 2010 were retrospectively analyzed, furthermore,the clinical data of the autoantibody-positive cases were reviewed. Results Among 2,714 serum specimens ,472 eases were positive for autoantibodies, with 17.4% positive rate,418 cases were positive for ANA, with 15.4% positive rate,124 cases were positive fo~!AMA,with 4.57% positive rate,91 cases were positive for ASMA, with 3.35% positive rate, t6 cases were positive for LKM, with 0.59% positive rate,8 cases were positive for LMA,with 0.29% positive rate ,5 eases were positive for LC-1, with 0.18% positive rate,3 cases were positive for LSP,with 0. 11% positive rate. Among 2,914 specimens, there were 59 cases of AIH, with 2. 17% positive rate,there were 61 cases of PBC, with 2.24% positive rate. The autoantibody-positive patients accounted for 74.57% ,who were diagnosed as viral hepatitis and related diseases. Conclusion The detection for autoantibody is a necessary condition for diagnosing autoimmune liver diseases, but these antibodies can also be found in viral hepatitis, drug-induced hepatitis and other diseases.