药物性肝炎136例分析

目的：分析136例药物性肝炎的病因和临床特点，以加深对药物性肝炎的认识。方法：根据服药史、临床表现、肝功能、血清标志及停药后的治疗效果综合判断。结果：引起肝损害的药物多见于中草药，特别是治疗皮肤病和风湿骨关节病、肾炎等疾病的中草药(28．68％)，抗结核药物(27．21％)，抗甲状腺药物(10．29％)和抗感染药物(5．88％)等。大多数药物性肝炎出现于服药后1～2月。HBSAg阳性者更易发生药物性肝炎及重症肝炎。结论：影响药物性肝炎的因素有药物种类、用药时间、联合用药、患者自身健康状况等。

An Analysis of Clinical Features of 136 Patients with Drug Hepatitis

Objective: To enhance the understanding of drug hepatitis by analyzing the etiology and clinical features of 136 cases with drug-induced liver disease.Method: 136 cases with drug-induced liver damage admitted to our hospital from 19992004 were reviewed according to their drug histories, clinical features, liver function tests and serum markers and responses to withdrawal.Result: The etiological drugs were herbal medicine (a(c)28.68%), anti-tuberculosis drugs (a(c)27.21%aa), antia2thyroid agent (a(c)10.29%aa), and anti-infectious drugs (a(c)5.88%), and also included antia2tumor agents (a(c)3.60%), anti-psychotic drugs (a(c)3.60%), and so on. Most of the drug hepatitis appeared during the first month to the second month of the treatment. Patients with HBSAg positive were at a higher risk of drug hepatitis,even severe hepatitis.Conclusion: Conclusion The factors to influence drug hepatitis include the kinds of drugs to be used,duration of drugs used,combined use of drugs,health condition,etc.