| Abstract: | 212 Wistar rats were divided randomly into fivegroups, each of which was fed on one of the follow
ing regimes: (1) Normal iodine and fluorine; (2)
normal iodine, 10 ppm fluorine; (3) normal iodine,
30 ppm fluorine; (4) flow iodine, normal fluorine;
(5) low iodine, 10 ppm fluorine. The experiment
lasted seven months. The results showed that severe
morphologic and functional damage of the thyroid
appeared in the rats drinking water containing 30
ppm fluorine, but only slight abnormal ultrastructural
changes of thyroid cells appeared in rats drinking
water containing 10 ppm fluorine; rats with iodine
deFiciency showed proliferative changes of the thy-
roid; rats on iodine deficient diet and drinking water
containing 10 ppm fluorine showed morphologic and
functional damage as well as proliferation. The
study suggests that there is synergistic action of
iodine-deficiency and fluorine-intoxication on the thy
roid. |
