| HPLC法测定卡络磺钠葡萄糖注射液中卡络磺钠的含量 |
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| 引用本文： | 黄顺旺,许龙,曹明成. HPLC法测定卡络磺钠葡萄糖注射液中卡络磺钠的含量[J]. 安徽医药, 2008, 12(2): 120-121 |
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| 作者姓名： | 黄顺旺 许龙 曹明成 |
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| 作者单位： | 合肥仁康医药科技有限公司,安徽,合肥230088;合肥仁康医药科技有限公司,安徽,合肥230088;沈阳药科大学现代社会药学研究中心,辽宁,沈阳110016 |
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| 摘 要： | 目的建立高效液相色谱法测定卡络磺钠葡萄糖注射液中卡络磺钠含量。方法采用C18色谱柱；以0.12％磷酸二氢铵溶液-乙腈（91：9）为流动相，流速为1 ml·min^-1；检测波长为363nm。结果卡络磺钠浓度在11.65-58.25mg·L^-1围内有良好的线性关系（r=0.9998），平均回收率为99.90％，RSD为1.19％。结论此法简便、快速、准确、专属性强，适用于卡络磺钠葡萄糖注射液中卡络磺钠的含量测定。
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| 关 键 词： | 卡络磺钠 测定 高效液相色谱法 |
| 收稿时间： | 2007-09-12 |
| 修稿时间： | 2007-09-12 |
Determination of carbazochrome sodium sulfonate in carbazochrome sodium sulfonate and glucose injection by HPLC |
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| HUANG Shun-wang,XU Long,CAO Ming-cheng. Determination of carbazochrome sodium sulfonate in carbazochrome sodium sulfonate and glucose injection by HPLC[J]. Anhui Medical and Pharmaceutical Journal, 2008, 12(2): 120-121 |
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| Authors: | HUANG Shun-wang XU Long CAO Ming-cheng |
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| Affiliation: | HUANG Shun-wang1 , XU Long1 , CAO Ming-cheng1,2 (1. Hefei Renkang Pharmaceutical Science and Technology CO. ,Ltd,Hefei 230088; 2. Research Center for Modern Social Pharmacy,Shenyang Pharmaceutical University,Shenyang110016 ) |
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| Abstract: | Aim To establish an HPLC method for the assay of carbazochrome sodium sulfonate and glucose injection. Methods The assay was performed on a Cls column. The mobile phase was composed of 0.12% NH4H2PO4： acetonitrile （91： 9）. The flow rate was 1 ml·min^-1. The detection wavelength was 363 nm. Results Carbazochrome sodium sulfonate showed good linear（ r = 0.9998 ） in the range between 11.65 and 55.25 mg·L^-1. The average recovery was 99.90%, and RSD bing 1.19%. Conclusion The method might be simple,rapid,accurate and specific. It is suitable for the assay of carbazochrome sodium sulfonate and glucose injection. |
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| Keywords: | carbazochrome sodium sulfonate and glucose injection determination HPLC |
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