Fasting serum cholecystokinin immunoreactivity in chronic relapsing pancreatitis |
| |
Authors: | Andrea Ederle Italo Vantini Richard F Harvey Giorgio Cavallini Walter Piubello Luigi Benini Ludovico Antonio Scuro |
| |
Institution: | (1) Istituto di Clinica Medica III dell'Università degli Studi di Padova, Sede di Verona Policlinico di Borgo Roma, 37100 Verona, Italia;(2) Department of Medicine, Bristol Royal Infirmary, Bristol, UK |
| |
Abstract: | Summary An increase in fasting cholecystokinia (CCK) levels has been reported in patients with pancreatic insufficiency, but the relationship
of these findings to the clinical conditions has not been established. We, therefore, measured fasting serum CCK-like immunoreactivity
in 70 patients with chronic relapsing pancreatitis (CRP) (38 non-surgically treated and 32 previously surgically treated)
and in 44 healthy subjects. The radioimmunoassay detected three circulating forms of CCK. The mean value of the CCK levels
in CRP (260.3±300.8 pg/ml) was significantly higher than that of the controls (56.6±61.7 pg/ml) (p<0.001), but in 39 (56.7%)
of the 70 CRP cases the CCK was in the normal range. A smaller overlap with the controls was observed in the non-surgically
than in the surgically treated patients (45 vs. 71.8%). In the 38 non-surgically treated CRP cases no relationship was observed
between the CCK levels and each of the following parameters: age, length of history, presence or absence of pancreatic calcification,
nutritional and alcoholic habits, and the results of exocrine function tests. The absence of the last-mentioned correlation
is some-what unexpected if the high CCK levels are due to the interruption of a feedback loop for CCK secretion. However,
previous pancreatic surgical drainage and/or treatment with pancreatic enzymes, present in almost all these patients, could
have an effect on CCK behaviour.
An abstract of this paper was presented at the 10th Meeting of the European Pancreatic Club, Dublin, October 1977. This research
was supported in part by a grant from theConsiglio Nazionale delle Ricerche (CNR), Roma, Italy, grant CT 77.01498.04. |
| |
Keywords: | Cholecystokinin Chronic pancreatitis Pancreozymin Radioimmunoassay |
本文献已被 SpringerLink 等数据库收录! |
|