遗传性非息肉病性大肠癌

目的：提高对遗传性非息肉病性大肠癌本质的认识。方法：对四个有遗传性非息肉病性大肠癌家系进行调查。结果：四家系共有14例病人，发病时平均年龄43岁。61．9％（13／21）的癌灶位于脾曲近端的大肠。大肠多原发癌占35．7％（5／14）。无结肠息肉病。四家系中之一为癌家族综合征。结论：对遗传性非息肉病性大肠癌前病人及其家系成员进行严密监测，争取疾病早诊断早治疗，提高治疗效果。

Hereditary nonpolyposis colorectal cancer

Objective To improve the recognition of the hereditary nonpolyposis colorectal cancer(HNPCC) in its essence. Methods A survey of 4 pedigrees of HNPCC patients was made. Results Among the 4 families, 14 persons had colorectal cancer. The average age of the cancer onset was 43 years(from 26 to54).61.9%(13/21) of the foci were located in the proximal colon to the splenic flexure. The patients having multifocal colorectal cancer account for 35.7% (5/14) of all cases.No colorectal polyposis was found in all cases. One of the four families had the familial carcinoma syndrome. Conclusions HNPCC patients and their family members should be followed up regularly for early diagnosis and treatment of the disease and for better prognosis.