| 红芪的化学成分及抗肿瘤作用研究进展 |
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| 引用本文： | 赵昱波,陈俊,许浚,张铁军.红芪的化学成分及抗肿瘤作用研究进展[J].中草药,2015,46(22):3434-3440. |
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| 作者姓名： | 赵昱波 陈俊 许浚 张铁军 |
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| 作者单位： | 吉林省梅河口市药品监督所, 吉林 梅河口 135000;天津中医药大学, 天津 300193;天津药物研究院, 天津 300193;天津中医药大学, 天津 300193;天津药物研究院, 天津 300193;中药现代制剂与质量控制技术国家地方联合工程实验室(天津), 天津 300193;天津药物研究院, 天津 300193;中药现代制剂与质量控制技术国家地方联合工程实验室(天津), 天津 300193 |
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| 摘 要： | 红芪主要含有糖类、黄酮类及苯丙素类等化学成分,在抗肿瘤方面有着广阔的应用前景。近年来对红芪的抗肿瘤作用研究较多,主要通过抑制肿瘤细胞的生长、诱导肿瘤细胞凋亡、上调机体免疫功能以及协同化疗药物等发挥抗肿瘤作用,其主要活性成分为红芪多糖,黄酮和皂苷也具有一定的抗肿瘤作用。综述了红芪的化学成分及抗肿瘤作用机制的研究进展,为其进一步开发利用提供理论依据。
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| 关 键 词： | 红芪 多糖 黄酮 皂苷 抗肿瘤 增强免疫 |
| 收稿时间： | 5/5/2015 12:00:00 AM |
Research progress in study on chemical constituents and antitumor effects in Hedysarum polybotrys |
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| ZHAO Yu-bo,CHEN Jun,XU Jun and ZHANG Tie-jun.Research progress in study on chemical constituents and antitumor effects in Hedysarum polybotrys[J].Chinese Traditional and Herbal Drugs,2015,46(22):3434-3440. |
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| Authors: | ZHAO Yu-bo CHEN Jun XU Jun and ZHANG Tie-jun |
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| Institution: | Meihekou Institute of Drug Supervision, Meihekou 135000, China;Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China;Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China;National & Local United Engineering Laboratory of Modern Preparation and Quality Control Technology of Traditional Chinese Medicine (Tianjin), Tianjin 300193, China;Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China;National & Local United Engineering Laboratory of Modern Preparation and Quality Control Technology of Traditional Chinese Medicine (Tianjin), Tianjin 300193, China |
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| Abstract: | Hedysari Radix (HR) mainly consists of chemical constituents such as sacchcrides, flavonoids, phenylpropanoids, etc. HR has broad application prospects in antitumor effect. In recent years, the researches on the antitumor function of HR are frequently reported, and the main active ingredients in HR are polysaccharides, flavonoids, and saponins. The active ingredients of HR mainly inhibit the growth of tumor cells, induce the apoptosis of tumor cells, enhance the immune system, and cooperate with chemotherapy drug to exert the antitumor effect. This paper reviews the advances of the chemical constituents and antitumor effects of HR, providing theoretical basis for its further development and utilization. |
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| Keywords: | Hedysari Radix polysaccharides flavonoids saponins antitumor immuno-enhancement |
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