| Treg/Th17与免疫性血小板减少症中医证型的相关性 |
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| 引用本文： | 郑雪倩,周韶虹,屠仁枫,陈英坤,胡明辉,胡令彦.Treg/Th17与免疫性血小板减少症中医证型的相关性[J].第二军医大学学报,2015,36(11):1254-1258. |
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| 作者姓名： | 郑雪倩 周韶虹 屠仁枫 陈英坤 胡明辉 胡令彦 |
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| 作者单位： | 上海中医药大学附属岳阳中西医结合医院血液科 200437,上海中医药大学附属岳阳中西医结合医院血液科 200437,上海中医药大学附属岳阳中西医结合医院血液科 200437,上海中医药大学附属岳阳中西医结合医院血液科 200437,上海中医药大学附属岳阳中西医结合医院血液科 200437,上海中医药大学附属岳阳中西医结合医院血液科 200437 |
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| 基金项目： | 上海市卫生局科研课题(20114035)；全国黄振翘名老中医传承工作室项目；上海市卫生局中药新药及院内制剂研发项目( 20112J018)；上海市科委中药现代化专项( 10DZ1974100；11DZ1971600)；上海市卫生局青年科研项目( 20124Y017) Supported by Shanghai Municipal Health Bureau Scientific Research Project (20114035);Huang Zhenqiao National Prominent TCM Doctors Studio Project ;Shanghai Municipal Health Bureau TCM New Medicine and Nosocomial Research and Development Project( 20112J018);Science and Technology Commission of Shanghai Municipality Modernization of Traditional Chinese Medicine Special Project(10DZ1974100；11DZ1971600); Shanghai Municipal Health Bureau Science and Research Project for Youth(20124Y017). |
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| 摘 要： | 摘要目的:探讨Treg/Th17 失衡在免疫性血小板减少症（ITP）中医“血热妄行”、“阴虚火旺”、“气不摄血”证型中的作用及意义；方法:流式细胞术（FCM）检测92例ITP患者（血热妄行组31例，阴虚火旺组31例，气不摄血组30例）及30例健康志愿者外周血Th17 细胞和Treg 细胞的数量;RT-PCR用于检测Foxp3 mRNA和ROR-γt水平,比较各组间上述指标的差异。结果：3组不同证型的ITP患者外周血treg细胞数量均低于正常对照组(p<0.05)，且血热妄行组低于气不摄血组(p<0.05)，气不摄血组低于阴虚火旺组(p<0.05),血热妄行组低于阴虚火旺组(p<0.05)，组间两两比较差异均有统计学意义。3组不同证型 ITP外周血Th17细胞数量显著高于正常对照组(p<0.05)，血热妄行组高于气不摄血组及阴虚火旺组(p<0.05)，比较差异有统计学意义。气不摄血组高于阴虚火旺组(p>0.05)，差异无统计学意义。3组Treg/Th17较对照组相比均降低(p<0.05)，血热妄行组低于气不摄血组(p<0.05)差异有统计学意义，气不摄血组低于阴虚火旺组(p<0.05)差异有统计学意义,血热妄行组低于阴虚火旺组(p<0.05)差异有统计学意义。3组不同证型的ITP患者Foxp3 mRNA水平均低于正常对照组(p<0.05)，且各组间两两比较差异有统计学意义。3组不同证型ROR-γt水平高于正常对照组（P＜0.01)。Treg 细胞数量表达水平、Foxp3 mRNA水平在ITP 各证型间的分布规律为血热妄行组＜气不摄血组＜阴虚火旺组。结论：ITP患者中Treg 细胞数量减少参与了ITP的发生发展，Treg/Th17比例失衡在ITP的发病机制中可能有重要作用。Treg 细胞数量表达水平、Foxp3 mRNA水平及Treg/Th17比例在不同中医证型ITP中有差异。
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| 关 键 词： | 特发性血小板减少性紫癜 调节性T淋巴细胞 Th17细胞 辨证分型 |
| 收稿时间： | 3/6/2015 12:00:00 AM |
| 修稿时间： | 2015/4/28 0:00:00 |
Correlation between Treg/Th17 and Traditonal Chinese Medicine syndrome differentiation classification in patients with immune thrombocytopenia |
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| ZHENG Xue-qian,ZHOU Shao-hong,TU Ren-feng,CHEN Ying-kun,HU Ming-hui and HU Ling-yan.Correlation between Treg/Th17 and Traditonal Chinese Medicine syndrome differentiation classification in patients with immune thrombocytopenia[J].Academic Journal of Second Military Medical University,2015,36(11):1254-1258. |
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| Authors: | ZHENG Xue-qian ZHOU Shao-hong TU Ren-feng CHEN Ying-kun HU Ming-hui and HU Ling-yan |
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| Institution: | Yueyang hospital of integrated traditional Chinese and western medicine,shanghai university of teaditional Chinese medicine,Yueyang hospital of integrated traditional Chinese and western medicine,shanghai university of teaditional Chinese medicine,Yueyang hospital of integrated traditional Chinese and western medicine,shanghai university of teaditional Chinese medicine,Yueyang hospital of integrated traditional Chinese and western medicine,shanghai university of teaditional Chinese medicine,Yueyang hospital of integrated traditional Chinese and western medicine,shanghai university of teaditional Chinese medicine,Yueyang hospital of integrated traditional Chinese and western medicine,shanghai university of teaditional Chinese medicine |
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| Abstract: | |
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| Keywords: | : Immune thrombocytopenia regulatory T-Lymphocyte cells Th17 cells syndrome differentiation classification |
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