| 长叶缬草化学成分的研究 |
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| 引用本文： | 柴士伟,翟永松,王满元. 长叶缬草化学成分的研究[J]. 中国中药杂志, 2015, 40(20): 4007-4011 |
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| 作者姓名： | 柴士伟 翟永松 王满元 |
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| 作者单位： | 天津中医药大学第一附属医院, 天津 300193,首都医科大学中医药学院, 北京 100069,首都医科大学中医药学院, 北京 100069 |
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| 基金项目： | 北京市属高等学校高层次人才引进与培养计划项目(CIT&TCD201304184) |
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| 摘 要： | 对长叶缬草的化学成分进行研究,通过硅胶、Sephadex LH-20柱色谱,制备TLC和反相制备HPLC分离技术,从长叶缬草全草的乙醇提取物中分离得到13个化合物,经MS和NMR等波谱技术鉴定了它们的结构,其中包括11个黄酮类化合物:6,8-二甲基芹菜素(1),6-甲基芹菜素(2),5-羟基-7,4'-二甲氧基黄酮(3),芫花素(4),金合欢素(5),芹菜素(6),槲皮素(7),麦黄酮(8),杜鹃素(9),异野樱素(10),5,3',4'-三羟基-7-甲氧基二氢黄酮(11); 2个单萜类化合物:(-)-bornyl ferulate(12)和(-)-bornyl caffeate(13)。所有化合物均为首次从该植物分离得到,化合物1,9~13为首次该从属植物中分离得到。
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| 关 键 词： | 缬草属 长叶缬草 化学成分 黄酮 单萜 |
| 收稿时间： | 2015-05-18 |
Chemical constituents from whole plants of Valeriana hardwickii |
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| CHAI Shi-wei,ZHAI Yong-song and WANG Man-yuan. Chemical constituents from whole plants of Valeriana hardwickii[J]. China Journal of Chinese Materia Medica, 2015, 40(20): 4007-4011 |
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| Authors: | CHAI Shi-wei ZHAI Yong-song WANG Man-yuan |
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| Affiliation: | The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China and School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China |
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| Abstract: | Chemical investigation of the whole plants of Valeriana hardwickii has led to the isolation of 11 flavones and 2 monoterpenoids by using various chromatographic techniques including column chromatography on silica gel and Sephadex LH-20, preparative TLC, and preparative HPLC. Their structures were identified by spectroscopic data analysis as syzalterin(1), 6-methylapigenin(2), 5-hydroxy-7,4'-dimethoxyflavone(3), genkwanin(4), acacetin(5), apigenin(6), quercetin(7), tricin(8),(-)-farrerol(9), isosakuranetin(10), 5,3',4'-trihydroxy-7-methoxyflavanone(11),(-)-bornyl ferulate(12), and(-)-bornyl caffeate(13). All compounds were isolated from this plant for the first time, while compounds 1, 9-13 were obtained from this genus for the first time. |
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| Keywords: | Valeriana Valeriana hardwickii chemical constituents flavones monoterpenoids |
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