B7-H4与移植免疫 |
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引用本文: | 金成彦,姜睿,赵吉光,孙梅,李金东,张兴义. B7-H4与移植免疫[J]. 中国实验诊断学, 2010, 14(6): 954-958 |
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作者姓名: | 金成彦 姜睿 赵吉光 孙梅 李金东 张兴义 |
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作者单位: | 1. 吉林大学白求恩第二医院,胸外科,吉林,长春,130041 2. 吉林大学中日联谊医院,骨科,吉林,长春,130033 3. 吉林大学白求恩第二医院,心血管内科,吉林,长春,130041 4. 吉林大学白求恩第二医院,病理科,吉林,长春,130041 |
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基金项目: | 国家自然科学基金,吉林省科技厅资助,吉林省发展与改革委员会资助,吉林省卫生厅科研资助,2007年吉林大学科研种子基金 |
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摘 要: | B7-H4是2003年发现的B7家族成员,在T细胞介导的免疫中起负调节作用,抑制T细胞增殖和细胞因子分泌。尽管其mRNA在淋巴组织和非淋巴组织均有表达,但其蛋白质在正常组织、细胞中不表达或极低表达。本文就B7-H4与移植免疫的相关研究进展作一综述。
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关 键 词: | B7-H4 共刺激分子 移植 免疫学 |
B7-H4 and transplantation immunology |
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Affiliation: | JIN Cheng-yan , JIANG Rui, ZHAO Ji-guang, et al. ( Dept. of Thoracic Surgeryl Cardiology, and Pathology, and the Second Bethune Hospital of Jilin University, Changchun 130041, China. Dept. of Orthopediac Surgery, Sino-Japan Union Hospital of Jilin University, Changchun 130033, China ) |
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Abstract: | B7-H4, a B7 family member, which was found in 2003 plays negatively regulating effect of T-cell mediated immune response via inhibiting T-cell proliferation and cytokines production. Although B7-H4 mRNA expression is seen in lymph and nonlymph tissues, protein is down-expressed or not expressed in normal tissues and cells. This study is to review advances in B7-H4 associated-transplantation immunology. |
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Keywords: | B7-H4 |
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