中药复康片对卡马西平致损伤大鼠股直肌运动单位电位的影响

目的:探讨中药复康片对卡马西平(CBZ)致大鼠肌纤维损害的保护效果。方法:将72只大鼠随机分为正常对照组、模型对照组、复康片低、高剂量预防组,复康片低、高剂量治疗组,每组12只。正常对照组正常喂养,每d灌胃蒸馏水,其余不做任何处理。其余5组按分步逐渐增加灌胃剂量法灌服CBZ。复康片低、高剂量预防组于灌服CBZ开始即分别给予复康片750mg/(kg·d)和1500mg/(kg·d)灌胃,1次/d。复康片低、高剂量治疗组于灌服CBZ30d后开始给予复康片,剂量同前。90d后,检查各组大鼠股直肌运动单位电位(MUP)的时限和波幅。结果:模型对照组大鼠股直肌MUP时限和波幅均较正常对照组降低(P<0.05),复康片高剂量预防和治疗组大鼠股直肌MUP的时程和波幅较模型对照组升高(P<0.05),而低剂量预防和治疗组大鼠仅股直肌MUP波幅较模型对照组升高(P<0.05)。结论:长期应用CBZ可对肌纤维造成损害;中药康复片对该损害有一定的防治作用。

Effect of Fukang tablet on motor unit potential of rectus femoris of rats injured by carbamazepine

Aim:To investigate the effect of carbamazepine on motor unit potential (MUP) of rectus femoris of rats and the protective effect of Fukang tablets. Methods: A total of 72 rats were randomly allocated into 6 groups.The normal control group was given distilled water,and the other 5 groups were given CBZ for 90 d. At the same time,low GA dose and high-dose Fukang tablet prevention groups were given Fukang tablet at 750 mg/kg and 1 500 mg/kg per day by gavage,and on the 30th d,the low-dose and high-dose Fukang tablet treatment groups were given Fukang tablet.After 90 d,the time course and amplitude of MUP of rectus femoris in the rats were examined. Results: The time course and amplitude of MUP in model group were both lower than those in normal control(P<0.05).Compared with model group,the 2 parameters increased in high-dose prevention and treatment groups(P<0.05),and only the amplitude of MUP increased in the low-dose prevention and treatment groups(P<0.05).Conclusion: Long-term administration of CBZ may injury the muscle,which can be prevented by Fukang tablet.