Peroral Immunization of Rats with Escherichia coli Heat-Labile Enterotoxin Delivered by Microspheres |
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| Authors: | Frederick A. Klipstein Richard F. Engert William T. Sherman |
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| Affiliation: | 1Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642;Department of Experimental Therapeutics, Johnson and Johnson Baby Products Company, Skillman, New Jersey 08558 |
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| Abstract: | The antigenicity of the Escherichia coli heat-labile enterotoxin was not protected against the adverse effect of gastric acidity when the toxin was given together with bicarbonate for peroral immunization to rats, but immunization with the heat-labile enterotoxin encapsulated in pH-dependent microspheres aroused the same strong degree of serum and mucosal antitoxin responses and of protection against challenge as was achieved by peroral immunization after ablation of gastric secretions by pretreatment with cimetidine. |
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