| Abstract: | Exchange blood replacement with perfluorotributylamine (PFTBA) emulsion was carried out in experiments on unanesthetized rats. During the period of blood exchange and for the next 5 days the rats were maintained on an increased oxygen concentration. On the sixth day the animals were returned to ordinary atmospheric conditions, and systematic observation commenced on that day and continued for 1 year. On the sixth day after exchange blood replacement, marked activation of erythropoiesis was found in the bone marrow of the rats and reticulocytosis in their peripheral blood. Meanwhile a decrease in the hemoglobin concentration and an increase in the number of lymphocytes and mature and immature neutrophils were found in the blood; immature erythropoietic cells-polychromatophilic erythroblasts and normoblasts-were present. The normal peripheral blood indices were completely restored by the 13th day and the morphological composition of the bone marrow by the 28th day; for the next 12 months hematopoiesis in the rats was maintained without appreciable deviations. It can be concluded from these results that the PFTBA emulsion has no adverse effect on hematopoiesis in animals and does not disturb the normal process of regulation of hematopoiesis under these experimental conditions.Laboratory of Pathological Physiology and Laboratory of New Blood Substitutes, Central Institute of Hematology and Blood Transfusion, Ministry of Health of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR N. A. Fedorov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 87, No. 6, pp. 531–533, June, 1979. |
