氨茶碱对缺氧动物吸入NO肺动脉高压反弹的预防效果观察

目的:评价氨茶碱对缺氧性动物吸入NO肺动脉高压反弹的预防作用。方法:采用右心漂浮导管检测法,由八导生理记录仪记录肺动脉平均压(mPAP),并监测呼吸、心率及动脉血氧分压变化。结果:急性缺氧猪吸入10^-5NO后,mPAP明显下降,突然停止吸入NO而改吸室内空气后,下降的mPAP逐渐回升,5min时恢复到吸入NO前水平,10min时已明显高于吸入NO前水平,与此同时,缺氧动物血氧分压反较吸入NO前低;而当急性缺氧猪在停止吸入NO的同时,静脉推注氨茶碱后,虽然下降的mPAP有所回升,但回升速度明显低于对照组,在停止吸入NO30min时仍低于吸入NO前水平。结论:氨茶碱对缺氧性动物吸入NO肺动脉高压反弹有明显的预防作用。

Preventive effects of aminophylline on the pulmonary hypertension rebound reaction to exposure to NO in the hypoxic pigs

AIM: To evaluate the prophylactic effect of aminophylline on the pulmonary hypertension rebound reaction to exposure to NO in the hypoxic pigs. METHODS: The 10 pigs undergone Swan-Ganz catheter, the mPAP was measured with a Physio-recording instrument and PaO₂ was measured with a blood gas analyzer, when breathing NO for 30 minutes and suddenly stopping breathing NO, administing aminophylline 0.25 g, followed by 30 minutes with room air. The respiratory rate and heart rate were also monitorried with a Hewlett-Packard portable monitor. RESULTS: The mPAP of the acute hypoxic pig was induced significantly after breathing 10^-5 NO. When suddenly stopping breathing NO, the induced mPAP became more and more high, the level of the mPAP in 5 minutes was similar to the values before absorbing NO, the mPAP in 10 minutes was higher than values before absorbing NO, while the level of PaO₂ was lower than the values before absorbing NO; but suddenly stopping breathing NO, administing aminophylline, although the induced mPAP became high, the speed was slower than the controls, the level of the mPAP in 30 minutes still was lower than the values before absorbing NO. CONCLUSION: Aminophylline has preventive effects on the pulmonary hypertension rebound reaction to exposure to NO in the hypoxic pigs.