| PPARδ的结构及其生物学功能与疾病 |
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| 引用本文： | 陈娜,吴英良.PPARδ的结构及其生物学功能与疾病[J].中国药理学通报,2006,22(9):1035-1038. |
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| 作者姓名： | 陈娜 吴英良 |
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| 作者单位： | 沈阳药科大学药学院药理系,辽宁,沈阳,110016 |
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| 摘 要： | PPARδ是过氧化物酶体增殖激活受体PPAR的一个亚型,主要控制脂肪组织和骨骼肌细胞的脂类代谢和能量解偶联,并参与许多疾病的发生和发展过程。PPARδ作为治疗靶标,它的合成激动剂有望开发成为治疗皮肤损伤和代谢综合症的有效药物。
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| 关 键 词： | PPARδ 脂类代谢 能量解偶联 皮肤损伤 代谢综合症 |
| 文章编号： | 1001-1978（2006）09-1035-04 |
| 收稿时间： | 2006-05-28 |
| 修稿时间： | 2006-06-29 |
A research on the structure and biological functions of PPARδ and its relationship with diseases |
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| CHEN Na,WU Ying-liang.A research on the structure and biological functions of PPARδ and its relationship with diseases[J].Chinese Pharmacological Bulletin,2006,22(9):1035-1038. |
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| Authors: | CHEN Na WU Ying-liang |
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| Institution: | Dept of Pharmacology, College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China |
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| Abstract: | PPAR δ is one of the three isoforms of peroxisome proliferator-activated receptors (PPARs) which are essential regulators of lipid storage and metabolism. PPAR δ primarily stimulats lipid metabolism and energy uncoupling in adipocytes and myocytes as well as involvs in the onset and development of many diseases. As the target of medicines, PPAR δ agonists may be powerful drugs for epidermal wound and metabolic syndrome X. |
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| Keywords: | PPARδ lipid metabolism energy uncoupling epidermal wound metabolic syndrome X |
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