糖尿病视网膜病变危险因素的临床分析

目的探讨糖尿病视网膜病变的相关危险因素。方法对合并糖尿病视网膜病变(DR)及不合并糖尿病视网膜病变(NDR)的两组糖尿病患者进行病例对照研究,了解病史,测定血压、空腹血糖、糖化血红蛋白、总胆固醇、甘油三脂、纤维蛋白原及尿微量白蛋白等指标,并进行比较。结果DR组157例,NDR组122例;两组的病程、空腹血糖、HbA1c、尿微量白蛋白、血浆纤维蛋白原及胆固醇水平等指标具有显著差异(P<0.05)。经Logistic回归分析,病程(OR:1.127)、糖化血红蛋白(OR:1.032)及尿微量白蛋白(OR:1.006)与DR发生为显著正相关(P<0.05)。结论糖尿病病程、糖化血红蛋白及尿微量白蛋白是糖尿病视网膜病变的独立危险因素。

Clinical study of risk factors of diabetic retinopathy in diabetes mellitus

Objective To evaluate the risk factors of diabetic retinopathy (PDR) in diabetic mellitus patients. Methods The clinical data including course of the disease, blood pressure, fasting blood sugar, glycosylated haemoglobin(HbAlc), total serum cholesterol, triglyceride, urine albumin, etc. were collected and analyzed by t test, x 2 test and Logistic regression. Results Compared with diabetic patients without retinopathy , longer course of the disease, higher levels of fasting blood glucose, HbA1c, urine albumin, total cholesterol and fibrinogen were observed in patients with diabetic retinopathy. DR was positively correlated with the course of the disease (OR: 1.127, P<0.05), HbA1c(OR: 1.032, P<0.05) and urine albumin(OR: 1.006, P<0.05). Conclusion The disease course, HbA1c and urine albumin levels are three independent risk factors for diabetic retinopathy in the patients with diabetes mellitus.