Signal transduction pathways and transcription factors triggered by arsenic trioxide in leukemia cells期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Signal transduction pathways and transcription factors triggered by arsenic trioxide in leukemia cells

Authors:	Daigo Sumi Yasuhiro Shinkai

Affiliation:	^a Faculty of Pharmaceutical Sciences, Tokushima Bunri University, 180, Yamashiro-cho, Tokushima-city, Tokushima 770-8514, Japan ^b Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki 305-8575, Japan

Abstract:

Keywords:	APL, acute promyelocytic leukemia As₂O₃, arsenic trioxide ASK1, apoptosis signal-regulating kinase 1 ERK1/2, extracellular signal-regulated kinase 1/2 GPx, glutathione peroxidase H₂O₂, hydrogen peroxide iAsIII, inorganic arsenite iAsV, inorganic arsenate IKK, inhibitor of κB kinase MAPKs, mitogen-activated protein kinases MEFs, mouse embryonic fibroblasts NAC, N-acetylcysteine NF-κB, nuclear factor-κB O₂^&bull &minus , superoxide PI3K, phosphatidylinositol 3-kinase ROS, reactive oxygen species SAPK/JNK, stress-activated protein kinase/Jun-N-terminal protein kinase TNF, tumor necrosis factor Trx, thioredoxin TrxR, thioredoxin reductase
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