|
|||||
|
|
Activation of the Nrf2/ARE pathway via S-alkylation of cysteine 151 in the chemopreventive agent-sensor Keap1 protein by falcarindiol, a conjugated diacetylene compound |
|
| Authors: | Tomokazu Ohnuma Eisaburo Anan Kenichiro Ogura |
| Institution: | a Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji-shi, Tokyo 192-0392, Japan b Toyama Chemical Co. Ltd., 3-2-5 Nishi-Shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan |
| Abstract: | |
| Keywords: | Keap1 Kelch-like ECH-associated protein 1 Nrf2 nuclear factor-E2-related factor 2 ARE antioxidant response element AOE antioxidant enzyme DME drug-metabolizing enzyme HMW high molecular weight |
| 本文献已被 ScienceDirect 等数据库收录！ | |