Intestinal Ischemia-Reperfusion Is Attenuated by Treatment With Atenolol in Rabbits |
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| Authors: | M.O. Taha,R. Miranda-Ferreira,R.S. Simõ es,I. Oliveira Jr,M.L. Modaelli-Filho,W.F. Magalhã es-Junior,E.S. Souza,J.A.S. Lemos,M.C. Simõ es,A. Caricati-Neto |
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| Affiliation: | Departments of Pharmacoloy, Biochemistry, Morphology and Surgery of the Federal University of São Paulo (UNIFESP) and Federal University of Great Dourados (UFGD), São Paulo, Brazil |
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| Abstract: | To study whether treatment with the beta-blocker atenolol (AT) attenuates intestinal dysfunction caused by ischemia (I) and reperfusion (R), rabbits were treated with AT (1 mg · kg−1, introvenously) or saline solution (SS) prior to I (60 minutes), which was produced by occlusion of the superior mesenteric artery, and/or R (120 minutes). After I or I/R, 2-cm jejunal segments were mounted in an organ bath to study neurogenic contractions stimulated by electrical pulses or KCl using a digital recording system. Thin jejunal slices were stained hematoxylin and eosin for analysis by optical microscopy. Compared to the sham group, the jejunal contractions were similar in the I + AT and the I/R + AT groups, but reduced in the I + SS and the I/R + SS groups. The jejunal enteric nerves were damaged in the I + SS and the I/R + SS groups, but not in the I + AT and the I/R + AT. These results suggest that AT may attenuate intestinal dysfunction caused by I and I/R. |
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