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Human Adipose Tissue-Derived Adult Stem Cells Can Lead to Multiorgan Engraftment |
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| Authors: | B. Fang Y. Li Y. Song N. Li X. Wei R.C. Zhao |
| Affiliation: | a Center of Excellence in Tissue Engineering, Henan Tumor Hospital, Henan Institute of Technology, Zhengzhou University, Zhengzho, China b Department of Gastroenterology, First Affiliated Hospital, Zhengzhou University, Zhengzho, China c Center of Excellence in Tissue Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China |
| Abstract: | Recent studies have demonstrated the existence of a population of adipose tissue-derived adult stem cells that can undergo multilineage differentiation in vitro; however, it is unclear whether these cells maintain their multilineage differentiation in vivo. The objective of the present study was to examine the in vivo characteristics and behavior of a potential population of human adipose tissue-derived adult stem cells. Herein, we demonstrate that human adipose tissue-derived adult stem cells differentiate into the epithelium of the gastrointestinal tract, liver, and bronchi, and an endothelial lineage after transplantation into irradiated nonobese mice with diabetes or severe combined immunodeficiency. These findings may contribute to clinical tissue repair after injury. |
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