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Ginsenoside Rg3 increases nitric oxide production via increases in phosphorylation and expression of endothelial nitric oxide synthase: Essential roles of estrogen receptor-dependent PI3-kinase and AMP-activated protein kinase |
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| Authors: | Tran Thi Hien Yuba Raj Pokharel Moo Yeol Lee |
| Affiliation: | a BK21 Project Team, College of Pharmacy, Chosun University, 375 Seosuk-dong, Dong-gu, Gwangju 501-759, South Korea b Seoul National University, Seoul 151-745, South Korea c College of Pharmacy, Chonnam National University, Gwangju 500-757, South Korea |
| Abstract: | |
| Keywords: | ACC, acetyl-CoA carboxylase ACh, acetylcholine AMPK, AMP-activated protein kinase CaMK II, calmodulin-dependent protein kinase II DAF-2, DA (4,5-diaminofluorescein diacetate) eNOS, endothelial nitric oxide synthase ER, estrogen receptor GR, glucocorticoid receptor smallcaps" >l-NAME, NG-nitro- smallcaps" >l-arginine methyl ester NF-κB, nuclear factor-κB NO, nitric oxide NOS, nitric oxide synthase PI3-kinase, phosphatidylinositol 3-kinase |
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