Activation of midline thalamic nuclei by antipsychotic drugs |
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Authors: | B M Cohen Weihua Wan Michael P Froimowitz David J Ennulat Sara Cherkerzian Hanna Konieczna |
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Institution: | (1) McLean Hospital, Mailman Research Center, Molecular Pharmacology Laboratory, 115 Mill Street, Belmont, MA 02178-9106, USA Fax (+1)617/855-3479, US |
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Abstract: | The thalamus has been proposed as a site which may be involved in the production of the syndrome of schizophrenia and the
response of schizophrenic symptoms to treatment. These studies test whether, consistent with this hypothesis, the activation
of thalamic nuclei is a shared property of neuroleptic antipsychotic drugs. Rats were given single doses of the typical high
and low potency neuroleptics haloperidol (1 mg/kg) and chlorpromazine (20 mg/kg), the atypical neuroleptics thiroridazine
(20 mg/kg) and clozapine (20 mg/kg), the specific dopamine antagonist raclopride (3 mg/kg), the mixed dopamine/serotonin antagonist
risperidone (3 mg/kg) or drug-free vehicle. Increased expression of Fos-like protein was utilized as a marker of cellular
activation. All drugs tested, including typical and atypical antipsychotic agents, led to similar effects on the midline thalamic
paraventricular, centromedian and rhomboid nuclei and the nucleus reuniens. These results suggest that midline thalamic nuclei
may participate in neural circuits mediating some of the shared effects of antipsychotic drugs.
Received: 9 January 1997/Final verion: 13 June 1997 |
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Keywords: | Neuroleptics Antipsychotic drugs Thalamus Fos immunohistochemistry Rat |
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