卵巢透明细胞癌的临床特点

目的 探讨卵巢透明细胞癌的临床特点。方法 将北京协和医科妇产科自1984年至2000年收治的43例卵巢透明细胞癌患者进行回顾性分析,并将卵巢透明细胞癌对化学药物治疗（化疗）的敏感性和生存率,与51例卵巢浆液性乳头状囊腺癌患者进行比较。结果 卵巢透明细胞癌早期患者所占比例为14．4％,浆液性乳头状囊腺癌为3．8％,两者比较,差异有极显著性（P＜0．005）。行满意肿瘤细胞减灭术的晚期透明细胞癌化疗耐药型患者为88．9％,明显多于浆液性乳头状囊腺癌患者的57．1％;1年生存率（79．0％）明显低于浆液性乳头状囊腺癌患者（96．2％,P＜0．01）;行不满意肿瘤细胞减灭术的晚期透明细胞癌患者化疗耐药型的比例（83．3％）和生存率（71．4％）与浆液性乳头状囊腺癌患者（94．1％和85．1％）比较,差异均无显著性（P＞0．05）。结论 卵巢透明细胞癌早期患者较多,易复发,预后差,应于术后进行以顺铂为主的化疗,并严密随诊。

Clinical characteristics of clear cell carcinoma of the ovary

Objective To study the clinical characteristics of clear cell carcinoma of the ovary. Methods Forty three patients with clear cell carcinoma of the ovary and 51 patients with serous adenocarcinoma of the ovary who were admitted in Peking Union Medical College Hospital between 1984 to 2000 were analyzed retrospectively, and their chemosensitivities and the survival rates were compared. Results The percentage of early stage patients in the clear cell carcinoma of the ovary and the serous adenocarcinoma of the ovary was 14 4% and 3 8% respectively, the difference was significant ( P <0 005). In the late stage patients who underwent satisfactory cytoreductive surgery, the chemo resistant rate (88 9%) in the clear cell carcinoma of the ovary was significantly higher than that (57 1%) of the serous adenocarcinoma of the ovary ( P <0 02), the 1 year survival rate (79 0%) in the clear cell carcinoma of the ovary was significantly lower than that (96 2%)of the serous adenocarcinoma of the ovary ( P <0 01). In the late stage patients who underwent unsatisfactory cytoreductive surgery, the chemo resistant rate and the survival rate had no significant difference between the clear cell carcinoma of the ovary and the serous adenocarcinoma of the ovary ( P >0 05). Conclusions There are more early stage patients with clear cell carcinoma of the ovary. We should conduct auxiliary therapy and close follow up to them after surgery. Clear cell carcinoma of the ovary is chemo resistant to platinum based chemotherapy and has poor prognosis.